Metronidazole 25mg for dogs
The kidneys and liver of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on: However, some infections may require longer treatment.
Either 2 grams g as a single dose or two divided doses of 1 g each on a single day, or mg three times per day for 7 days. Symptoms of overdose may include nausea, vomiting, dizziness, loss of balance or coordination, or seizures.
What should I avoid while giving metronidazole to my pet? Antibiotic medications can cause diarrhea, which may be the sign of a new infection.
If your pet has diarrhea that is watery or has blood in it, call your veterinarian. Do not use any medication to stop the diarrhea unless your veterinarian tells you to do so. What other drugs will affect metronidazole? Tell your veterinarian if your pet is using any of the following medications: There may be other drugs not listed that can affect metronidazole.
Tell your veterinarian about all prescription and non-prescription OTC medications, including vitamins, minerals, herbal products, and drugs prescribed by other veterinarians. Do not start using a new medication without telling your veterinarian. Metronidazole also tends to reduce the inflammation of bowels.
Metronidazole is not FDA-approved for use in veterinary medicine; however, it is widely accepted practice for veterinarians to use this medication in dogs. Commonly when given to dogs, this drug is termed as Flagyl. Anaerobic infections in dogs generally occur at sites such as mouth, gastrointestinal tract, deep wounds, vagina, internal organs and surgery or wound locations.
Metronidazole for dogs also acts against a prevalent irritable bowel syndrome Metronidazole For Dogs thanks to its immune modulating activity in addition to non-specific diarrhea. Veterinarians also recommend this drug for periodontal problems, an onset of tetanus and cases of pancreatic insufficiency along with small intestinal bacterial overgrowth SIBO.
Pregnancy Category B There are no adequate and well controlled studies of Metronidazole tablets in pregnant women. There are published data from case-control studies, cohort studies, and 2 meta-analyses that include more than pregnant women who used Metronidazole during pregnancy. Many studies included first trimester exposures. One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to Metronidazole in-utero; however, these findings were not confirmed.
In addition, more than ten randomized placebo-controlled clinical trials enrolled more than pregnant women to assess the use of antibiotic treatment including Metronidazole for bacterial vaginosis on the incidence of preterm delivery. Most studies did not show an increased risk for congenital anomalies or other adverse fetal outcomes following Metronidazole exposure during pregnancy. Three studies conducted to assess the risk of infant cancer following Metronidazole exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limited.
Metronidazole crosses the placental barrier and its effects on the human fetal organogenesis are not known. Reproduction studies have been performed in rats, rabbits, and mice at doses similar to the maximum recommended human dose based on body surface area comparisons. There was no evidence of harm to the fetus due to Metronidazole. Nursing Mothers Metronidazole is present in human milk at concentrations similar to maternal serum levels, and infant serum levels can be close to or comparable to infant therapeutic levels.
Because of the potential for tumorigenicity shown for Metronidazole in mouse and rat studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use Safety and effectiveness in pediatric patients have not been established, except for the treatment of amebiasis. Adverse Reactions The following reactions have been reported during treatment with Metronidazole: The most serious adverse reactions reported in patients treated with Metronidazole have been convulsive seizures, encephalopathy, aseptic meningitis, optic and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity.
Since persistent peripheral neuropathy has been reported in some patients receiving prolonged administration of Metronidazole, patients should be specifically warned about these reactions and should be told to stop the drug and report immediately to their physicians if any neurologic symptoms occur.
In addition, patients have reported headache, syncope, dizziness, vertigo, incoordination, ataxia, confusion, dysarthria, irritability, depression, weakness, and insomnia see WARNINGS. The most common adverse reactions reported have been referable to the gastrointestinal tract, particularly nausea, sometimes accompanied by headache, anorexia, and occasionally vomiting; diarrhea; epigastric distress; and abdominal cramping and constipation.
A sharp, unpleasant metallic taste is not unusual. Furry tongue, glossitis, and stomatitis have occurred; these may be associated with a sudden overgrowth of Candida which may occur during therapy. Erythematous rash and pruritus. Reversible neutropenia leukopenia ; rarely, reversible thrombocytopenia.
Flattening of the T-wave may be seen in electrocardiographic tracings. Urticaria, erythematous rash, Stevens-Johnson Syndrome, toxic epidermal necrolysis, flushing, nasal congestion, dryness of the mouth or vagina or vulva , and fever.
Dysuria, cystitis, polyuria, incontinence, and a sense of pelvic pressure. Instances of darkened urine have been reported by approximately one patient in , Although the pigment which is probably responsible for this phenomenon has not been positively identified, it is almost certainly a metabolite of Metronidazole and seems to have no clinical significance.
Metronidazole for Dogs – Is It Safe To Use?
Symptoms reported include nausea, vomiting, and ataxia. Reproduction studies have been performed in rats, rabbits, and mice at doses similar to the maximum recommended human dose based on body surface area comparisons. Symptoms of toxicity begin to manifest themselves anywhere between days after the dog has started taking the medication. Metronidazole What is the most important thing I should know about metronidazole? Drugs That Induce CYP Enzymes The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbitalmay accelerate the elimination of metronidazole, for in reduced viagra pattaya kaufen levels; impaired clearance of phenytoin has also been reported. A cause and effect relationship has not been established, metronidazole 25mg for dogs. Details Antiprotozoal Antibiotics for Dogs and Cats Metronidazole is an antibiotic for dogs and cats that also works as an antiprotozoal medication. Your kidneys help clear this drug from your body. Lithium In patients stabilized on relatively high doses of lithiumshort-term metronidazole therapy has been associated with elevation of serum lithium and, in a few cases, signs of lithium toxicity. Veterinarians also recommend this drug for periodontal problems, an onset of tetanus metronidazole cases of pancreatic insufficiency along with small intestinal bacterial overgrowth SIBO. When on this medication, canines show signs of extreme salivation, retching, reflux, regurgitation, mouth pawing, queasiness or vomiting. Medical dog is a must. Severe side effects may result from high doses. One study showed an increased risk of cleft lipwith or without cleft palatein infants exposed to 25mg in-utero; however, these findings were not confirmed. If you know of or suspect an overdose, seek emergency veterinary treatment.
Metronidazole, Oral Tablet
Because it can penetrate your dog's blood-brain barrier, it's also prescribed 25mg infections of the central nervous system. Metronidazole does not possess any clinically relevant activity against facultative anaerobes or obligate dogs. The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment. Not for use in young puppies and kittens. Metronidazole Neurotoxicity Dogs on high or long-term doses of metronidazole might develop neurological for relating to drug toxicity. Metronidazole tablets Bactrim 150mg are indicated in the treatment of asymptomatic T. Values of zero may be observed. Use exactly as prescribed by your veterinarian. Precautions and Contraindications Pregnant or nursing dogs or young puppies should not receive metronidazole. Studies reveal no metronidazole bioavailability differences between males and females; however, because of weight differences, the resulting plasma levels in males are generally lower. Renal Impairment Decreased renal function does not alter the singledose-pharmacokinetics of metronidazole. You must note that in case you pet pooch is afflicted with such toxicity or side-effects, you cannot help him at home. Pediatric Patients In one study, newborn infants appeared to demonstrate diminished capacity to eliminate metronidazole, metronidazole 25mg for dogs. Severe liver ailments can also be brought under control using this medication. Do not allow children to handle or administer Metronidazole. Tell your veterinarian if your pet is pregnant or lactating, or if you plan to breed your pet. Metronidazole tablets USP are indicated for the treatment of T.