Bactrim 150mg
Even treatment with recommended doses may cause hyperkalemia when trimethoprim is administered to patients with underlying disorders of potassium metabolism, with renal insufficiency, or if drugs known to induce hyperkalemia are given concomitantly. Close monitoring of serum potassium is warranted in these patients. Evaluation for hyponatremia and appropriate correction is necessary in symptomatic patients to prevent life-threatening complications. During treatment, adequate fluid intake and urinary output should be ensured to prevent crystalluria.
Patients who are "slow acetylators" may be more prone to idiosyncratic reactions to sulfonamides. Patients should be counseled that antibacterial drugs including Bactrim sulfamethoxazole and trimethoprim tablets should only be used to treat bacterial infections. They do not treat viral infections e. When Bactrim sulfamethoxazole and trimethoprim tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by Bactrim sulfamethoxazole and trimethoprim tablets or other antibacterial drugs in the future. Patients should be instructed to maintain an adequate fluid intake in order to prevent crystalluria and stone formation.
Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic.
If this occurs, patients should contact their physician as soon as possible. Urinalyses with careful microscopic examination and renal function tests should be performed during therapy, particularly for those patients with impaired renal function. Sulfamethoxazole is an inhibitor of CYP2C9.
In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. This interaction should be kept in mind when BACTRIM is given to patients already on anticoagulant therapy, and the coagulation time should be reassessed. When administering these drugs concurrently, one should be alert for possible excessive phenytoin effect. Sulfonamides can also displace methotrexate from plasma protein binding sites and can compete with the renal transport of methotrexate, thus increasing free methotrexate concentrations.
There have been reports of marked but reversible nephrotoxicity with coadministration of BACTRIM and cyclosporine in renal transplant recipients. Serum digoxin levels should be monitored. Increased sulfamethoxazole blood levels may occur in patients who are also receiving indomethacin.
Occasional reports suggest that patients receiving pyrimethamine as malaria prophylaxis in doses exceeding 25 mg weekly may develop megaloblastic anemia if BACTRIM is prescribed. Additional monitoring of blood glucose may be warranted.
Cases of interactions with other OCT2 substrates, memantine and metformin, have also been reported. BACTRIM, specifically the trimethoprim component, can interfere with a serum methotrexate assay as determined by the competitive binding protein technique CBPA when a bacterial dihydrofolate reductase is used as the binding protein.
No interference occurs, however, if methotrexate is measured by a radioimmunoassay RIA. Carcinogenesis, Mutagenesis, Impairment of Fertility: In vitro reverse mutation bacterial tests according to the standard protocol have not been performed with sulfamethoxazole and trimethoprim in combination.
Observations of leukocytes obtained from patients treated with sulfamethoxazole and trimethoprim revealed no chromosomal abnormalities. Sulfamethoxazole alone was positive in an in vitro reverse mutation bacterial assay and in in vitro micronucleus assays using cultured human lymphocytes. Trimethoprim alone was negative in in vitro reverse mutation bacterial assays and in in vitro chromosomal aberration assays with Chinese Hamster ovary or lung cells with or without S9 activation.
In in vitro Comet, micronucleus and chromosomal damage assays using cultured human lymphocytes, trimethoprim was positive. In mice following oral administration of trimethoprim, no DNA damage in Comet assays of liver, kidney, lung, spleen, or bone marrow was recorded.
While there are no large, well-controlled studies on the use of sulfamethoxazole and trimethoprim in pregnant women, Brumfitt and Pursell,10 in a retrospective study, reported the outcome of pregnancies during which the mother received either placebo or sulfamethoxazole and trimethoprim. The incidence of congenital abnormalities was 4. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester.
In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral sulfamethoxazole and trimethoprim at the time of conception or shortly thereafter. Because sulfamethoxazole and trimethoprim may interfere with folic acid metabolism, BACTRIM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. These studies, however, were limited by the small number of exposed cases and the lack of adjustment for multiple statistical comparisons and confounders.
These studies are further limited by recall, selection, and information biases, and by limited generalizability of their findings. Lastly, outcome measures varied between studies, limiting cross-study comparisons. These doses are approximately 5 and 6 times the recommended human total daily dose on a body surface area basis. In some rabbit studies, an overall increase in fetal loss dead and resorbed conceptuses was associated with doses of trimethoprim 6 times the human therapeutic dose based on body surface area.
Caution should be exercised when BACTRIM is administered to a nursing woman, especially when breastfeeding, jaundiced, ill, stressed, or premature infants because of the potential risk of bilirubin displacement and kernicterus. Clinical studies of BACTRIM did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. There may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist, e.
In those concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported.
Hematological changes indicative of folic acid deficiency may occur in elderly patients. Encouraging your child to eat a small snack before taking a dose of Bactrim can help limit the development of upset stomach symptoms in certain children.
Contact your child's pediatrician immediately if you notice blood in your child's stools or if diarrhea worsens. Sleeping Difficulties You may notice that your child has difficulty staying asleep during treatment with Bactrim, explains Drugs.
This medication can cause your child to feel anxious or restless, which can cause him to appear unusually hyperactive or energetic. If your child does not sleep well during the night, he may be very tired during the day, which can affect his ability to remain focused or alert during school or while at home. Talk with your child's pediatrician if sleeping difficulties persist or worsen with continued Bactrim use. Mood or Behavior Changes Bactrim can cause your child to develop abnormal mood or behavioral changes as a side effect of treatment, warn health officials at the U.
Food and Drug Administration. You may notice that your child appears unusually irritable, cranky or confused and can cry or fuss more frequently than usual.
These side effects typically subside with recurrent use of this medication. Skin Rash A skin rash can develop as a severe side effect of Bactrim in certain children, explains Drugs. Your child may complain that his skin hurts or may frequently scratch at the affected skin region. If you notice the appearance of red, irritated or dry patches of skin on any part of your child's body, contact your pediatrician immediately for further evaluation and care.
Yeast Infection Bactrim is an antibacterial medication that can decrease the levels of naturally occurring bacteria within your child's body, explain Roche medical officials.
Bactrim DS
You may also observe unusual genital discharge that is thick or white while 150mg are changing your child's diaper or helping her use the toilet, bactrim 150mg. Traveler's Diarrhea in Adults: Phenylalanine metabolism Trimethoprim has been noted to impair phenylalanine metabolism, but this is of no significance in phenylketonuric patients on appropriate bactrim restriction. Mood or Behavior Changes Bactrim can cause your child to develop abnormal mood or behavioral changes as a side effect of treatment, warn health officials at the U. In the absence of such data, local epidemiology and susceptibility patterns may contribute to bactrim selection of therapy. For the treatment of urinary tract infections due to susceptible strains of the following organisms: No interference occurs, however, if methotrexate is measured by a radioimmunoassay RIA. Prescription Drugs If your child has a bacterial infection, such as an ear or urinary tract infection, your pediatrician may prescribe Bactrim to help resolve the symptoms of infection. Precautions Development 150mg drug resistant bacteria Prescribing Bactrim sulfamethoxazole and trimethoprim 150mg in the absence of a proven or strongly suspected bacterial infection or bactrim prophylactic indication is unlikely to provide benefit to the patient and increases the risk of 150mg development of maxalt 10mg packungsbeilage bacteria, bactrim 150mg. While there are no large, well-controlled 150mg on the use of sulfamethoxazole and trimethoprim in pregnant women, Brumfitt and Pursell,10 in a retrospective study, reported the outcome of pregnancies during which the mother bactrim either placebo or sulfamethoxazole and trimethoprim. Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic bactrim with oliguria and anuria, crystalluria and nephrotoxicity in association with cyclosporine. Hemolysis In glucosephosphate dehydrogenase deficient individuals, hemolysis may occur, bactrim 150mg. There may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist, e.
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Cross-sensitivity may exist with these agents. Clinical signs, bactrim 150mg, such as rash, sore throat, fever, arthralgia, pallor, purpura or jaundice may be early indications of serious reactions. During treatment, adequate fluid intake and urinary output should be ensured to prevent crystalluria. 150mg and Other Fatal Reactions Fatalities associated with the administration of sulfonamides, although rare, have occurred due to 150mg reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia and other blood dyscrasias. In mice following oral administration of trimethoprim, no DNA 150mg in Comet assays of liver, kidney, lung, spleen, bactrim 150mg, or bone marrow was recorded, bactrim 150mg. Cases of interactions with other OCT2 substrates, memantine and metformin, bactrim also been reported. Prescription Drugs If your child has a bacterial infection, such as an ear or urinary tract infection, your pediatrician may prescribe Bactrim to help resolve the symptoms of infection. Bactrim DS Tablets contain 3. Close monitoring of serum potassium is warranted in these patients. Talk with your child's pediatrician if sleeping difficulties persist or worsen with continued Bactrim use. In those concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. Pharmacokinetics parameters for sulfamethoxazole were similar for geriatric subjects and younger adult subjects. CDAD must be bactrim in all patients who present with diarrhea following antibiotic use. When Bactrim sulfamethoxazole and bactrim tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Lastly, outcome measures varied between studies, bactrim 150mg, limiting cross-study comparisons.