Information about hydrocodone apap

Do not use extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of acetaminophen and hydrocodone can be fatal. Overdose symptoms may include extreme drowsiness, sweating, pinpoint pupils, nausea, vomiting, dark urine, jaundice yellowing of the skin or eyes , confusion, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing.

What should I avoid? This medication can cause side effects that may impair your thinking or reactions. Do not use any other over-the-counter cough, cold, allergy, or pain medication without first asking your doctor or pharmacist.

Acetaminophen is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen. Avoid drinking alcohol while taking acetaminophen and hydrocodone. Alcohol may increase your risk of liver damage while taking acetaminophen.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, antidepressants, or seizure medication can add to sleepiness caused by hydrocodone, or could slow your breathing. Tell your doctor if you need to use any of these other medicines while you are taking acetaminophen and hydrocodone.

Acetaminophen and hydrocodone side effects Get emergency medical help if you have any of these signs of an allergic reaction: Call your doctor at once if you have any of these serious side effects: Less serious side effects include: Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion.

In adults, hepatic toxicity has rarely been reported with acute overdoses of less than 10 grams, or fatalities with less than 15 grams. Treatment A single or multiple overdose with hydrocodone and acetaminophen is a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended. Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption.

Vomiting should be induced mechanically, or with syrup of ipecac , if the patient is alert adequate pharyngeal and laryngeal reflexes. The first dose should be accompanied by an appropriate cathartic. If repeated doses are used, the cathartic might be included with alternate doses as required. Hypotension is usually hypovolemic and should respond to fluids. Vasopressors and other supportive measures should be employed as indicated.

A cuffed endotracheal tube should be inserted before gastric lavage of the unconscious patient and, when necessary, to provide assisted respiration. Meticulous attention should be given to maintaining adequate pulmonary ventilation. In severe cases of intoxication, peritoneal dialysis , or preferably hemodialysis may be considered. If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously.

Naloxone , a narcotic antagonist , can reverse respiratory depression and coma associated with opioid overdose. Since the duration of action of hydrocodone may exceed that of the naloxone, the patient should be kept under continuous surveillance and repeated doses of the antagonist should be administered as needed to maintain adequate respiration.

A narcotic antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Serum acetaminophen levels should be obtained, since levels four or more hours following ingestion help predict acetaminophen toxicity. Do not await acetaminophen assay results before initiating treatment.

Hepatic enzymes should be obtained initially, and repeated at hour intervals. The toxic dose for adults for acetaminophen is 10 g. This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you.

Dizziness or severe drowsiness can cause falls or other accidents. Hydrocodone side effects Get emergency medical help if you have any of these signs of an allergic reaction to hydrocodone: Like other opioid medicines, hydrocodone can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using hydrocodone and call your doctor at once if you have: Seek medical attention right away if you have symptoms of serotonin syndrome, such as: Long-term use of opioid medication may affect fertility ability to have children in men or women.

It is not known whether opioid effects on fertility are permanent. Common hydrocodone side effects may include: This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Hydrocodone dosing information Usual Adult Dose for Pain: Hydrocodone ER should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain.

The dose should be increased in increments of 10 mg orally every 12 hours every 3 to 7 days as needed to achieve adequate analgesia. Hydrocodone ER should be titrated to a dose that provides adequate analgesia and minimizes adverse reactions. Patients should be monitored routinely to assess the maintenance of pain control and incidence of adverse reactions, as well as monitoring for the development of addiction, abuse, or misuse.

Patients who experience breakthrough pain may require a dose increase, or may need a rescue medication with an appropriate dose of an immediate-release analgesic. The dose should be adjusted to obtain an appropriate balance between management of pain and adverse reactions. A single dose of hydrocodone ER greater than 40 or 50 mg, or a total daily dose greater than 80 mg are only for patients in whom tolerance to an opioid of comparable potency is established.

Dangerous side effects may result. Tell your doctor about all other medicines you use, especially: This list is not complete and other drugs may interact with acetaminophen and hydrocodone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Where can I get more information? Your pharmacist can provide more information about acetaminophen and hydrocodone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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