Possible side effects 5. How to store Valsartan 6. Contents of the pack and other information 1. What Valsartan is and what it is used for Valsartan contains valsartan as an active ingredient that belongs to a class of medicines known as angiotensin II receptor antagonist, which help to control high blood pressure.
Angiotensin II is a substance in the body that causes vessels to tighten, thus causing your blood pressure to increase. Valsartan works by blocking the effect of angiotensin II.
As a result, blood vessels relax and blood pressure is lowered. Valsartan tablets can be used for three different conditions: High blood pressure increases the workload on the heart and arteries. If not treated it can damage the blood vessels of the brain, heart, and kidneys, and may result in a stroke, heart failure, or kidney failure. High blood pressure increases the risk of heart attacks. Lowering your blood pressure to normal reduces the risk of developing these disorders - to treat people after a recent heart attack myocardial infarction.
Valsartan is used when a group of medicines called Angiotensin Converting Enzyme ACE inhibitors a medication to treat heart failure cannot be used or it may be used in addition to ACE inhibitors when other medications to treat heart failure cannot be used. Heart failure symptoms include shortness of breath, and swelling of the feet and legs.
It is caused when the heart muscle cannot pump blood strongly enough to supply all the blood needed throughout the body. What you need to know before you take Valsartan - if you are allergic to valsartan or any of the other ingredients of this medicine listed in section 6. If any of these apply to you, do not take Valsartan.
Talk to your doctor or pharmacist before taking Valsartan - if you have liver disease. These include potassium supplements or salt substitutes containing potassium, potassium-sparing medicines and heparin. It may be necessary to check the amount of potassium in your blood at regular intervals.
This is a disease in which your adrenal glands make too much of the hormone aldosterone. If this applies to you, the use of Valsartan is not recommended. You must tell your doctor if you think you are or might become pregnant. Valsartan is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage see pregnancy section.
Your doctor may check your kidney function, blood pressure, and the amount of electrolytes e. Tell your doctor or pharmacist if you are taking have recently taken or might take any other medicines. The effect of the treatment can be influenced if Valsartan is taken together with certain other medicines. This applies to both prescription and non-prescription medicines, especially: Its empirical formula is C24H29N5O3, its molecular weight is Valsartan is a white to practically white fine powder.
It is soluble in ethanol and methanol and slightly soluble in water. Valsartan Tablets, USP are available as tablets for oral administration, containing 40 mg, 80 mg, mg or mg of valsartan. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium.
Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.
There is also an AT2 receptor found in many tissues, but AT2 is not known to be associated with cardiovascular homeostasis. Valsartan has much greater affinity about 20,fold for the AT1 receptor than for the AT2 receptor. The increased plasma levels of angiotensin II following AT1 receptor blockade with valsartan may stimulate the unblocked AT2 receptor. The primary metabolite of valsartan is essentially inactive with an affinity for the AT1 receptor about oneth that of valsartan itself.
Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. Whether this difference has clinical relevance is not yet known. Valsartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of valsartan on blood pressure. No information on the effect of larger doses is available. Removal of the negative feedback of angiotensin II causes a 2- to 3-fold rise in plasma renin and consequent rise in angiotensin II plasma concentration in hypertensive patients.
Minimal decreases in plasma aldosterone were observed after administration of valsartan; very little effect on serum potassium was observed. In multiple-dose studies in hypertensive patients with stable renal insufficiency and patients with renovascular hypertension, valsartan had no clinically significant effects on glomerular filtration rate, filtration fraction, creatinine clearance, or renal plasma flow. In multiple-dose studies in hypertensive patients, valsartan had no notable effects on total cholesterol, fasting triglycerides, fasting serum glucose, or uric acid.
Valsartan shows bi-exponential decay kinetics following intravenous administration, with an average elimination half-life of about 6 hours. The bioavailability of the suspension [see Dosage and Administration; Pediatric Hypertension 2. AUC and Cmax values of valsartan increase approximately linearly with increasing dose over the clinical dosing range.
Valsartan does not accumulate appreciably in plasma following repeated administration. In vitro metabolism studies involving recombinant CYP enzymes indicated that the CYP 2C9 isoenzyme is responsible for the formation of valerylhydroxy valsartan.
Pregnancy and breast-feeding Ask your doctor or pharmacist for advice before taking any medicine. Your doctor will normally advise you to stop taking Valsartan before you become pregnant or as soon as you know you are pregnant, and will advise you to take another medicine instead of Valsartan. Valsartan is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if it is used after the third month of pregnancy.
Valsartan is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely. Driving and using machines Before you drive a vehicle, use tools or operate machines, or carry out other activities that require concentration, make sure you know how Valsartan affects you.
Like many other medicines used to treat high blood pressure, Valsartan may in rare cases cause dizziness and affect the ability to concentrate. You should check with your doctor or pharmacist if you are not sure. People with high blood pressure often do not notice any signs of this problem. Many may feel quite normal.
Tell your doctor or pharmacist hexal you are taking 80mg recently taken or might take any other medicines, valsartan hexal 80mg nebenwirkungen. Valsartan was excreted in the milk of lactating rats; however, animal breast milk drug levels may not nebenwirkungen reflect human breast milk levels. Valsartan, breast-feeding and fertility If you are pregnant or breast-feeding, valsartan hexal 80mg nebenwirkungen, think you may be valsartan or are planning to have a baby ask your doctor or pharmacist for advice before hexal this medicine. There were no notable differences in efficacy or safety between older and younger patients in either trial. How to store Valsartan 6. Possible side effects 5. As a result, blood vessels relax and blood pressure is lowered, valsartan hexal 80mg nebenwirkungen. What you need to know 80mg you nebenwirkungen Valsartan - if you are allergic to valsartan or any of nebenwirkungen other ingredients of this medicine listed in section 6. Removal of the negative feedback of angiotensin II causes a 2- to 3-fold rise in plasma renin and consequent rise in angiotensin II plasma concentration in valsartan patients. Valsartan is not recommended for pediatric patients under 6 years of nebenwirkungen due to safety findings for which benadryl 25mg iv relationship to treatment could not be excluded [see Adverse Reactions, Pediatric Hypertension 6, valsartan hexal 80mg nebenwirkungen. In patients who 80mg less than hexal kg the usual 80mg is 40 mg of valsartan once daily. The steady state volume of distribution of valsartan after intravenous administration is small 17 Lindicating that valsartan does not distribute into tissues extensively. It may harm them, valsartan if their signs of illness are the same as hexal.
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