Panic Zombie numbness hunger confusion - I needed an a personal assistant. This was obviously a drug I could only take if I wasn't going anywhere for Full on Ozzie Osborne. This continued 3 wks. I've gained 15 lbs. Feel horrid, had seizures, suicidal, confused about what to do.
Instantly cured my inability to stay asleep, and the last two weeks my mood has improved massively. Really starting to enjoy doing things and becoming sociable again; after a year of pure misery suffering with depression.
Would recommend for those suffering depression, particularly those with sleep issues. The effects of mirtazapine on sleep: Sleep, 25 6 , Mirtazapine provokes periodic leg movements during sleep in young healthy men. Sleep, 36 5 , Joe Aug 14, 2: Remeron causes the worse morning depression imaginable. It is like waking up in a concentration camp. At least Ambien makes you a little cheerful. However, Remeron is monstrous in the morning.
I have no idea how many lives this horrible drug has destroyed. My question is what in the heck where they thinking when this drug was concocted. Did they have any knowledge of how the human brain works? Keep it simple and take 1mg of Xanax. Stay away from this crap drugs like Zoloft school shooting drug , Paxil, and Prozac another school shooting drug. Evidence gathered in preclinical studies suggests that mirtazapine enhances central noradrenergic and serotonergic activity.
Mirtazapine is a potent antagonist of 5-HT2 and 5-HT3 receptors. Mirtazapine is a potent antagonist of histamine H1 receptors, a property that may explain its prominent sedative effects. Mirtazapine is a moderate antagonist at muscarinic receptors, a property that may explain the relatively low incidence of anticholinergic side effects associated with its use.
Pharmacokinetics REMERON mirtazapine Tablets are rapidly and completely absorbed following oral administration and have a half-life of about 20 to 40 hours.
Peak plasma concentrations are reached within about 2 hours following an oral dose. The presence of food in the stomach has a minimal effect on both the rate and extent of absorption and does not require a dosage adjustment. Mirtazapine is extensively metabolized after oral administration.
Major pathways of biotransformation are demethylation and hydroxylation followed by glucuronide conjugation. In vitro data from human liver microsomes indicate that cytochrome 2D6 and 1A2 are involved in the formation of the 8-hydroxy metabolite of mirtazapine, whereas cytochrome 3A is considered to be responsible for the formation of the N-desmethyl and N-oxide metabolite. Several unconjugated metabolites possess pharmacological activity but are present in the plasma at very low levels.
Plasma levels are linearly related to dose over a dose range of 15 to 80 mg. The mean elimination halflife of mirtazapine after oral administration ranges from approximately 20 to 40 hours across age and gender subgroups, with females of all ages exhibiting significantly longer elimination half-lives than males mean half-life of 37 hours for females vs. Gender The mean elimination half-life of mirtazapine after oral administration ranges from approximately 20 to 40 hours across age and gender subgroups, with females of all ages exhibiting significantly longer elimination half-lives than males mean half-life of 37 hours for females vs.
Renal Insufficiency The disposition of mirtazapine was studied in patients with varying degrees of renal function. Elimination of mirtazapine is correlated with creatinine clearance. Overall, these studies demonstrated mirtazapine to be superior to placebo on at least 3 of the following 4 measures: A fifth study of similar design utilized a higher dose up to 50 mg per day and also showed effectiveness.
Examination of age and gender subsets of the population did not reveal any differential responsiveness on the basis of these subgroupings. Relapse during the double-blind phase was determined by the individual investigators.
Patients receiving continued REMERON treatment experienced significantly lower relapse rates over the subsequent 40 weeks compared to those receiving placebo. This pattern was demonstrated in both male and female patients.
What happens if I overdose? Seek emergency medical attention or call the Poison Help line at Overdose symptoms may include confusion, memory problems, drowsiness, and fast heart rate. What should I avoid while taking mirtazapine? It may increase certain side effects of mirtazapine. Mirtazapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Mirtazapine side effects Get emergency medical help if you have any signs of an allergic reaction to mirtazapine:
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