Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension , renal failure, and death. Hypotension In patients with an activated renin-angiotensin system, such as volume-or salt-depleted patients e.
If hypotension does occur, the patient should be placed in the supine position and, if necessary, given an intravenous infusion of normal saline. A transient hypotensive response is not a contraindication to further treatment, which usually can be continued without difficulty once the blood pressure has stabilized.
Hyperkalemia Hyperkalemia may occur in patients on ARBs, particularly in patients with advanced renal impairment, heart failure , on renal replacement therapy, or on potassium supplements, potassium-sparing diuretics, potassium-containing salt substitutes or other drugs that increase potassium levels.
Consider periodic determinations of serum electrolytes to detect possible electrolyte imbalances, particularly in patients at risk. Impaired Hepatic Function As the majority of telmisartan is eliminated by biliary excretion, patients with biliary obstructive disorders or hepatic insufficiency can be expected to have reduced clearance.
Impaired Renal Function As a consequence of inhibiting the renin-angiotensin- aldosterone system, anticipate changes in renal function in susceptible individuals. In patients whose renal function may depend on the activity of the renin-angiotensin-aldosterone system e. In studies of ACE inhibitors in patients with unilateral or bilateral renal artery stenosis , increases in serum creatinine or blood urea nitrogen were observed.
Dual Blockade Of The Renin-Angiotensin-Aldosterone System Dual blockade of the RAS with angiotensin-receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure compared to monotherapy.
Patients receiving the combination of MICARDIS and ramipril did not obtain any additional benefit compared to monotherapy, but experienced an increased incidence of renal dysfunction e.
In most patients no benefit has been associated with using two RAS inhibitors concomitantly. In general, avoid combined use of RAS inhibitors.
Discuss treatment options with women planning to become pregnant. Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility There was no evidence of carcinogenicity when telmisartan was administered in the diet to mice and rats for up to 2 years. Genotoxicity assays did not reveal any telmisartan-related effects at either the gene or chromosome level.
These assays included bacterial mutagenicity tests with Salmonella and E. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. Use effective birth control.
It is not known whether telmisartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take Micardis? Take Micardis exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take Micardis with or without food. Do not crush, chew, or break a Micardis tablet.
Swallow the tablet whole. Keep each tablet in its blister pack until you are ready to take it. Tear or cut the blister apart from the rest of the package and peel back the paper liner. You may feel dizzy or light-headed when you begin to take Micardis, especially if you are also taking a diuretic or fluid tablet or if you are dehydrated. If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly.
Standing up slowly, especially when you get up from a bed or chair, will help your body get used to the change in position and blood pressure. If this problem continues or gets worse, talk to your doctor. If you exercise, or if you sweat, or if the weather is hot, you should drink plenty of water.
Side effects Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Micardis. All medicines can have side effects.
Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects. Do not be alarmed by the following list of possible side effects. You may not experience any of them. Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you: Store at room temperature away from moisture and heat. What happens if I miss a dose Micardis? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose Micardis? Seek emergency medical attention or call the Poison Help line at Possible side effects of Dinortes: Common side effects may affect up to 1 in 10 people: Low blood pressure hypotension in users treated for reduction of cardiovascular events.
Urinary tract infections,upper respiratory tract infections e. Rare side effects may affect up to 1 in 1, people: However, it is not known whether telmisartan was the cause. Reporting of side effects If you get any side effects, talk to your doctor or pharmacist.
This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme, website: By reporting side effects you can help provide more information on the safety of this medicine. How to store Dinortes Keep this medicine out of the sight and reach of children.
Furthermore, low blood pressure may be aggravated by alcohol, medicine micardis 40mg, barbiturates, narcotics or antidepressants. What other micardis will affect telmisartan Micardis? Micardis dosing information Usual Adult Dose for Hypertension: This depends on your condition and whether or not you are taking any other medicines. How should I take telmisartan Micardis? It can lower your blood pressure and may increase some of the side effects of telmisartan. During initial clinical studies, a single case of angioedema was reported among a total of patients treated. Store Micardis tablets in their original package at room temperature, away from moisture and heat. There were no changes in the heart rate of patients treated with telmisartan in controlled trials. If you take too much overdose Immediately telephone your doctor or Poisons Information Centre medicine 13 11 26 for advice or go to Emergency at your nearest hospital, if 40mg think that you or anyone else may have taken too much Micardis. At doses of 20, 40, and 80 mg, the antihypertensive effect of once daily administration of telmisartan is maintained for the full hour dose interval. For reduction of cardiovascular events, the usual dose of Dinortesis one 80 mg tablet once a day.
The mean duration of follow up was about 4 years and 6 months, medicine micardis 40mg. At medicines of 20, 40, and 80 mg, medicine micardis 40mg, the antihypertensive effect of once daily administration of telmisartan is maintained for the full hour dose interval. Do not crush, chew, or break a Micardis tablet. Side effects Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Micardis. Angiotensin II is 40mg principal pressor 40mg of the renin-angiotensin system, with effects that include vasoconstrictionstimulation of synthesis and release of aldosteronecardiac stimulation, medicine micardis 40mg, and renal reabsorption of micardis. Harga doxycycline 100mg of telmisartan micardis not result in a clinically significant interaction with acetaminophenmedicine micardis 40mg, amlodipine, glyburide, simvastatin, hydrochlorothiazide, warfarin, or ibuprofen. These medicines may be affected by Micardis, or may affect how well it works. Consider periodic determinations of serum electrolytes to detect medicine electrolyte imbalances, particularly in patients at risk. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal medicines. If you have trouble remembering when to take your medicine, ask your micardis for some hints. Take the missed dose as soon as you remember. Micardis is 40mg to treat high blood pressure hypertension. If this problem continues or gets worse, talk to your doctor. Ask your pharmacist how to throw away medicines you no longer use. Common side effects may affect up to 1 in 10 people: Do this even if there are no signs of discomfort or poisoning, medicine micardis 40mg.
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