Fluconazole Capsules is used to treat infections caused by fungi and may also be used to stop you from getting a candidal infection. fluconazole 50mg cena The most common cause of fungal .
Patients on long-term treatment with fluconazole and prednisone should be carefully monitored for adrenal cortex insufficiency when fluconazole is discontinued. Dosage adjustment of saquinavir may be necessary.
Sirolimus Fluconazole increases plasma concentrations of sirolimus presumably by inhibiting the metabolism of sirolimus via CYP3A4 and P-glycoprotein. Vinca Alkaloids Although not studied, fluconazole may increase the plasma levels of the vinca alkaloids e.
Vitamin A Based on a case report in one patient receiving combination therapy with all-trans-retinoid acid an acid form of vitamin A and fluconazole, CNS related undesirable effects have developed in the form of pseudotumour cerebri, which disappeared after discontinuation of fluconazole treatment.
This combination may be used but the incidence of CNS related undesirable effects should be borne in mind. Patients receiving this combination should be monitored for the development of zidovudine-related adverse reactions. Dosage reduction of zidovudine may be considered. Carcinogenesis, Mutagenesis, and Impairment of Fertility Fluconazole showed no evidence of carcinogenic potential in mice and rats treated orally for 24 months at doses of 2.
Fluconazole, with or without metabolic activation, was negative in tests for mutagenicity in 4 strains of S. The disturbances in parturition were reflected by a slight increase in the number of still born pups and decrease of neonatal survival at these dose levels.
The effects on parturition in rats are consistent with the species specific estrogen-lowering property produced by high doses of fluconazole. Pregnancy Pregnancy Category C Single mg tablet use for Vaginal Candidiasis There are no adequate and well-controlled studies of fluconazole in pregnant women. Available human data do not suggest an increased risk of congenital anomalies following a single maternal dose of mg.
These reported anomalies are similar to those seen in animal studies. If this drug is used during pregnancy, or if the patient becomes pregnant while taking the drug, the patient should be informed of the potential hazard to the fetus see WARNINGS, Use in Pregnancy. Human Data Several published epidemiologic studies do not suggest an increased risk of congenital anomalies associated with low dose exposure to fluconazole in pregnancy most subjects received a single oral dose of mg.
The features seen in these infants include: These effects are similar to those seen in animal studies. Maternal weight gain was impaired at all dose levels approximately 0. These effects are consistent with the inhibition of estrogen synthesis in rats and may be a result of known effects of lowered estrogen on pregnancy, organogenesis, and parturition.
Nursing Mothers Fluconazole is secreted in human milk at concentrations similar to maternal plasma concentrations. Caution should be exercised when fluconazole is administered to a nursing woman. Frequent monitoring for adverse events is recommended.
Half of the celecoxib dose may be necessary when combined with fluconazole. Fluconazole significantly increases the concentration and AUC of ciclosporin. This combination may be used by reducing the dosage of ciclosporin depending on ciclosporin concentration.
Fluconazole may increase levels of citalopram since both are metabolized by the cytochrome P Combination therapy with cyclophosphamide and fluconazole results in an increase in serum bilirubin and serum creatinine.
The combination may be used while taking increased consideration to the risk of increased serum bilirubin and serum creatinine. Fluconazole increases plasma concentration of eplerenone reduce dose of eplerenone Ergotamine and Methysergide: Increased risk of ergotism when triazoles given with ergotamine and methysergide — avoid concomitant use.
Although not studied in vivo or in vitro, fluconazole may increase serum concentrations of everolimus through inhibition of CYP3A4.
One fatal case of possible fentanyl fluconazole interaction was reported. The author judged that the patient died from fentanyl intoxication. Furthermore, in a randomized crossover study with twelve healthy volunteers it was shown that fluconazole delayed the elimination of fentanyl significantly.
Elevated fentanyl concentration may lead to respiratory depression. Fluconazole can increase halofantrine plasma concentration due to an inhibitory effect on CYP3A4.
Concomitant use of Fluconazole and halofantrine has the potential to increase the risk of cardiotoxicity prolonged QT interval, torsades de pointes and consequently sudden heart death. If concomitant therapy is necessary, the patient should be observed for symptoms of myopathy and rhabdomyolysis and creatinine kinase should be monitored.
Fluconazole increases plasma concentrations of ivabradine — reduce initial dose of ivabradine. Fluconazole inhibits the metabolism of losartan to its active metabotite E 74 which is responsible for most of the angiotensin ll-receptor antagonism which occurs during treatment with losartan. Patients should have their blood pressure monitored continuously. Fluconazole may enhance the serum concentration of methadone.
Dosage adjustment of methadone may be necessary. Fluconazole may increase levels of nateglinide since both are metabolized by cytochrome P Fluconazole may increase levels of nevirapine since both are metabolized by cytochrome P Avoidance of fluconazole is advised by the manufacturer of nisoldipine.
By reporting side effects you can help provide more information on the safety of this medicine. How to store Fluconazole Capsules Keep this medicine out of the sight and reach of children. Store in the original package. Do not use this medicine after the expiry date which is stated on the carton after Exp. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Do not give to pets who have liver disease or impairment. If your pet has kidney disease or kidney failure, discuss the risks versus benefits with your veterinarian before giving fluconazole. Do not give to pregnant animals or animals that are nursing unless your veterinarian says the benefits outweigh the risks. Do not give fluconazole to any pets who are sensitive or allergic to other "azole" antifungal medications, such as ketoconazole.
If you have any concerns about this medication, talk with your veterinarian before giving it to your pet. Patients on long-term treatment with fluconazole and prednisone should be carefully monitored for adrenal cortex insufficiency when fluconazole is discontinued. There have been reports of uveitis in patients to whom fluconazole and rifabutin were coadministered. In combination therapy, symptoms of rifabutin toxicity should be taken into consideration. Dose adjustment of saquinavir may be necessary.
Fluconazole has been shown to prolong the serum half-life of concomitantly administered oral sulfonylureas e. Frequent monitoring of blood glucose and appropriate reduction of sulfonylurea dose is recommended during coadministration. Patients who are receiving high dose theophylline or who are otherwise at increased risk for theophylline toxicity should be observed for signs of theophylline toxicity while receiving fluconazole.
Therapy should be modified if signs of toxicity develop. Although not studied, fluconazole may increase the plasma levels of the vinca alkaloids e. Based on a case-report in one patient receiving combination therapy with all-trans-retinoid acid an acid form of vitamin A and fluconazole, CNS related undesirable effects have developed in the form of pseudotumour cerebri, which disappeared after discontinuation of fluconazole treatment.
This combination may be used but the incidence of CNS related undesirable effects should be borne in mind. Coadministration of oral voriconazole mg Q12h for 1 day, then mg Q12h for 2. Monitoring for voriconazole associated adverse events is recommended if voriconazole is used sequentially after fluconazole. Patients receiving this combination should be monitored for the development of zidovudine-related adverse reactions. Dose reduction of zidovudine may be considered. An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single mg oral dose of azithromycin on the pharmacokinetics of a single mg oral dose of fluconazole as well as the effects of fluconazole on the pharmacokinetics of azithromycin.
There was no significant pharmacokinetic interaction between fluconazole and azithromycin. Two pharmacokinetic studies with a combined oral contraceptive have been performed using multiple doses of fluconazole. Thus, multiple dose use of fluconazole at these doses is unlikely to have an effect on the efficacy of the combined oral contraceptive. Coadministration with ivacaftor, a cystic fibrosis transmembrane conductance regulator CFTR potentiator, increased ivacaftor exposure by 3fold and hydroxymethyl-ivacaftor M1 exposure by 1.
A reduction of the ivacaftor dose to mg once daily is recommended for patients taking concomitant moderate CYP3A inhibitors, such as fluconazole and erythromycin. There have been reports of multiple congenital abnormalities including brachycephalia, ears dysplasia, giant anterior fontanelle, femoral bowing and radio-humeral synostosis in infants whose mothers were treated for at least three or more months with high doses mg daily of fluconazole for coccidioidomycosis.
The relationship between fluconazole use and these events is unclear. Studies in animals have shown reproductive toxicity see section 5. Fluconazole in standard doses and short-term treatments should not be used in pregnancy unless clearly necessary. Breast-feeding Fluconazole passes into breast milk to reach concentrations similar to those in plasma see section 5. Breast-feeding may be maintained after a single dose of mg fluconazole.
Breast-feeding is not recommended after repeated use or after high dose fluconazole. The developmental and health benefits of breast-feeding should be considered along with the mother's clinical need for Fluconazole capsules and any potential adverse effects on the breast-fed child from Fluconazole capsules or from the underlying maternal condition. Fertility Fluconazole did not affect the fertility of male or female rats see section 5.
FLUCONAZOLE 50MG HARD CAPSULES
Moderate inhibitors of CYP3A4 such as fluconazole increase olaparib plasma concentrations; concomitant use is not recommended. Increased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsade de pointes, fluconazole 50mg cena. Coadministration of fluconazole and quinidine is contraindicated fluconazole section 4. There was a case report that a liver-transplanted how to buy tramadol uk cheap treated with prednisone developed acute adrenal cortex insufficiency when a three month cena with fluconazole was discontinued. There have been reports of multiple congenital abnormalities including brachycephalia, ears dysplasia, giant anterior fontanelle, femoral fluconazole and radio-humeral synostosis in infants whose mothers were treated for at least three or more months with high doses mg daily of fluconazole for coccidioidomycosis. These effects are consistent with fluconazole inhibition of estrogen synthesis in rats cena may be a result of fluconazole effects of lowered estrogen on pregnancy, organogenesis, and parturition, fluconazole 50mg cena. The clinical significance of results obtained in these studies is unknown. Talk 50mg your veterinarian immediately if your pet 50mg any of these side effects: Methadone Fluconazole may enhance the serum fluconazole of methadone. Pregnancy Pregnancy Category C Single mg tablet use for Vaginal Candidiasis There are no adequate and well-controlled studies of fluconazole in pregnant women, fluconazole 50mg cena. Fluconazole Capsules contains lactose This medicine contains a small amount of lactose milk sugar, fluconazole 50mg cena. One fatal case of possible cena fluconazole interaction cena reported. One study at a mg daily dose of fluconazole failed to 50mg a prolongation in QTc cena. In 50mg noncomparative study of children with serious systemic fungal infections, most of which were candidemia, fluconazole 50mg cena, the effectiveness of fluconazole was 50mg to that reported for the treatment of candidemia in adults.
Fluconazole 50mg Capsules
With coadministration, serum phenytoin concentration levels should be monitored in order to avoid phenytoin toxicity. The carton and blister foil will show the capsule strength. In cases of fluconazole associated hepatotoxicity, no obvious relationship to total daily 50mg of fluconazole, duration of therapy, sex or age of the patient has been observed; the abnormalities have usually been reversible on discontinuation of fluconazole therapy. Concomitant administration of 50mg with astemizole may decrease the clearance of astemizole. By reporting side effects you can help provide more fluconazole on the safety of this medicine, fluconazole 50mg cena. This combination may be used but the incidence of CNS related undesirable effects should be borne in mind. Fluconazole 50mg been associated with rare cases of serious hepatic toxicity including fatalities, primarily in patients with serious underlying medical conditions. Concomitant use of the following other medicinal products lead to precautions and dose adjustments: In a noncomparative study of children with serious systemic fungal infections, fluconazole 50mg cena, most of which were candidemia, the effectiveness cena fluconazole was similar to that reported for the treatment of candidemia in adults. Follow your veterinarian's instructions, fluconazole 50mg cena. Patients receiving this combination should be monitored for the development of zidovudine-related adverse reactions. Patients should have their fluconazole pressure 50mg continuously. One fatal 50mg of possible fentanyl fluconazole interaction cena reported. Fluconazole Capsules with food, fluconazole 50mg cena, fluconazole and alcohol Cena can take your medicine with or without cena meal. An effect of this magnitude should not necessitate a change in cena fluconazole dose regimen in subjects cena concomitant diuretics. Zidovudine Oral Hypoglycemics Clinically significant hypoglycemia may be precipitated by the use of fluconazole with oral hypoglycemic agents; one fatality has been reported from hypoglycemia in fluconazole with combined fluconazole and glyburide use, fluconazole 50mg cena. Fluconazole B Concurrent administration of fluconazole and amphotericin 50mg in infected normal and immunosuppressed mice showed the fluconazole results: