This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. What is the most important information I should know about sertraline Zoloft?

Do not take sertraline if you have used an MAO inhibitor such as furazolidone Furoxone , isocarboxazid Marplan , phenelzine Nardil , rasagiline Azilect , selegiline Eldepryl, Emsam, Zelapar , or tranylcypromine Parnate in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Sertraline is known as a selective serotonin reuptake inhibitor SSRI. It works by helping to restore the balance of a certain natural substance serotonin in the brain.

How to use Zoloft Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using sertraline and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Arthralgia, myalgia Uncommon 0. Back pain , muscle weakness, muscle twitching, osteoarthritis Rare less than 0. Bone disorder Frequency not reported: Bone fracture , lupus -like syndrome, rigidity, trismus[ Ref ] Epidemiological studies, primarily in patients aged 50 years or older, have shown an increased risk of bone fractures in patients receiving SSRIs or TCAs.

Eye pain, mydriasis, periorbital edema Rare less than 0. Diplopia, glaucoma , hyphema, lacrimal disorder, photophobia, scotoma, visual field defect Frequency not reported: Blurred vision, unequal pupils Postmarketing reports: Blindness, cataract , optic neuritis [ Ref ] Oncologic There was one case of neoplasm reported in one patient receiving sertraline the active ingredient contained in Zoloft compared to no cases in the placebo-treated group.

Neoplasm[ Ref ] Renal Uncommon 0. Acute renal failure[ Ref ] Respiratory Uncommon 0. Bronchospasm, dyspnea , epistaxis, rhinitis, upper respiratory tract infection Rare less than 0. Dysphonia, hiccups , hyperventilation, hypoventilation, laryngospasm, stridor Frequency not reported: Physicians are advised to maintain patients on the lowest therapeutically effective dose of Zoloft to treat anxiety disorders.

Zoloft is an antidepressant medication classified as a serotonin reuptake inhibitor SSRI. Zoloft is indicated for the treatment of many different conditions including anxiety disorders. The mechanism of action of Zoloft appears to be related to its ability to inhibit central nervous system CNS uptake of serotonin.

Is there a Zoloft generic? There is currently a generic equivalent available for Zoloft sertraline , known as sertraline. Food and Drug Administration FDA requires that generic medications be bioequivalent to the brand-name medication and, therefore, work the same way in the body.

Generic medications are considered, by the FDA, to be identical to the brand-name counterparts in dose, strength, route of administration, safety, efficacy and intended use. Generic medications will appear differently and may have different inactive ingredients, however, the labeling and directions for use remain the same. For most medications, generic equivalents are a lower-cost alternative to the more expensive brand-name medication, and the majority of patients observe no changes in therapeutic effect.

However, some patients will experience a change in effect and must continue treatment with the brand-name medication. Generic Zoloft, sertraline, is a selective serotonin reuptake inhibitor SSRI type of antidepressant which is approved for the treatment of depression, obsessive-compulsive disorder OCD , certain anxiety disorders, panic disorder, premenstrual dysphoric disorder PMDD and post-traumatic stress disorder PTSD.

Frequently reported side effects for generic Zoloft are similar those observed in patients being treated with the brand-name medication and may include somnolence, dizziness, headache, nausea, diarrhea, fatigue, insomnia, dry mouth, tremor, increased sweating and sexual dysfunction.

The warnings and precautions associated with Zoloft are also possible with the generic Zoloft. According to the prescribing information for Zoloft, warnings and precautions, possible with treatment, include clinical worsening of depression and suicide risk, serotonin syndrome, activation of mania or hypomania, weight loss, seizures, abnormal bleeding and withdrawal symptoms upon abrupt discontinuation of treatment.

Generic Zoloft should be administered exactly the same as the brand-name medication. Sertraline is indicated to be taken once daily at the same time of day, morning or evening. Sertraline can be taken without regard to food. Generic Zoloft should be prescribed at the lowest therapeutically effective dose. Is there a Zoloft liquid? There is currently a Zoloft sertraline liquid formulation available.

The Zoloft liquid formulation is a clear, colorless solution with a menthol scent. It is available in two ounce bottles with an accompanying dropper to ensure accurate dose measurement.

Bottles of Zoloft Oral Concentrate should be stored at controlled room temperature away from moisture and heat. Zoloft liquid must be diluted prior to administration. Do not mix the Zoloft Oral Concentrate with any other liquids than those recommended. Patients should be instructed to administer the dose immediately after mixing and caution not to mix in advance.

Often times a slight haze appears after mixing and is normal. According to the prescribing information, patients with a latex sensitivity should exercise caution as the dropper dispenser contains dry natural rubber. Zoloft Oral Concentrate is contraindicated with Antabuse disulfiram because of the alcohol content of the concentrate.

Zoloft liquid is an antidepressant belonging to the selective serotonin reuptake inhibitor SSRI class of medications which has been approved, by the U. Similar to Zoloft tablets, Zoloft liquid may take four weeks or longer to achieve full therapeutic activity and before patients begin to feel better.

Patients are advised not to discontinue treatment with Zoloft liquid without first consulting with a physician to avoid unpleasant withdrawal effects including agitation, irritability, dizziness, sensory disturbances, headache, confusion, insomnia, dysphoric mood, lethargy and anxiety.

Zoloft sertraline is not considered a monoamine oxidase inhibitor MAOI. Rather, Zoloft is an antidepressant which is classified as a selective serotonin reuptake inhibitor SSRI. MAOIs are antidepressants indicated for the treatment of depression. MAOIs are generally used in the treatment of patients with atypical depression and in those patients who do not respond to treatment with other antidepressants.

The mechanism of action of the MAO inhibitors involves the inhibition of the enzyme monoamine oxidase and, therefore, prevents the breakdown of neurotransmitters, such as norepinephrine, dopamine, epinephrine and serotonin, causing an increase in their concentration and availability.

As a result of the potentially life-threatening drug and dietary interactions with MAO inhibitors, this class of antidepressants is rarely a first-line treatment for depression and is typically reserved as a last-line of therapy.

SSRIs are chemically unrelated to other available antidepressants. SSRIs are approved for a variety of indications. SSRIs are often times used as a first-line treatment for major depressive disorder. Zoloft, specifically, is approved for the treatment of depression, obsessive-compulsive disorder OCD , panic disorder, post-traumatic stress disorder PTSD , premenstrual dysphoric disorder PMDD and social anxiety disorder.

The mechanism of action of the Zoloft is believed to be linked to the inhibition of central nervous system CNS neuronal uptake of serotonin. Zoloft does not inhibit monoamine oxidase. According to clinical studies of certain SSRIs, such as Zoloft, they may also exhibit weak effects on the reuptake of other neurotransmitters including norepinephrine and dopamine. MAO inhibitors should not be administered concomitantly with, or within two weeks of, SSRIs, such as Zoloft, because of the potential for serious, life-threatening adverse reactions.

What are the common Zoloft side effects? During clinical trials, the most common Zoloft sertraline side effects included nausea, ejaculation failure in men, insomnia, diarrhea, dry mouth, somnolence, dizziness, tremor, fatigue, increased sweating and decreased libido. Some of the common Zoloft side effects that led to discontinuation of treatment include nausea, diarrhea and insomnia.

Zoloft is a selective serotonin reuptake inhibitor type of antidepressant, commonly referred to as an SSRI. Zoloft has been approved, by the U. Zoloft is used for the treatment of certain anxiety disorders, panic disorder, post-traumatic stress disorder PTSD , premenstrual dysphoric disorder PMDD , obsessive-compulsive disorder OCD and major depressive disorder.

Zoloft exerts its antidepressant activity by inhibiting the neuronal uptake of serotonin in the central nervous system. Less common Zoloft side effects are also possible with treatment. If you experience more serious side effects while taking Zoloft, it is important to contact your physician immediately or seek medical attention when necessary.

Symptoms indicating a patient may be experiencing a more serious Zoloft side effect include changes in mood or behavior, suicidal ideation or behavior, anxiety, panic attacks, difficulty sleeping, impulsivity, irritability, agitation, hostility, aggressive behavior, restlessness, physical or mental hyperactivity, worsening depression, stiff muscles, high fever, sweating, rapid heartbeat, loss of appetite, loss of coordination, difficulty concentrating, memory disturbances, weakness, confusion, hallucinations, fainting, seizures or difficulty breathing.

In addition to the side effects possible with treatment, Zoloft also carries several warnings or precautions.

Precautions with regard to Zoloft involve suicidality, serotonin syndrome, hypomania or mania, weight loss, seizures, abnormal bleeding, hyponatremia and altered platelet function. It is important for patients to be counseled regarding these precautions prior to beginning treatment with Zoloft. How should I take Zoloft and Chantix together? Although no documented drug interaction or contraindication exists between Zoloft sertraline and Chantix varenicline , both medications have similar black box warnings regarding the possible risk for suicidality and serious neuropsychiatric adverse events, respectively.

Therefore, taking Zoloft and Chantix together may increase the risk for worsening depression, suicidal thoughts and behaviors and precipitate a dangerous, life-threatening situation. According to the black box warning, there is a potential risk for serious neuropsychiatric events associated with treatment with Chantix. Possible neuropsychiatric events may include depression, suicidal ideation, suicide attempt and completed suicide have all been reported in patients being treated with Chantix.

While depressed mood may be an indication of a neuropsychiatric event, it may also be a symptom of nicotine withdrawal as patients have experienced depression, rarely associated with suicidal ideation, upon smoking cessation without treatment.

Patients with a diagnosis of schizophrenia, bipolar disorder and major depressive disorder did not participate in the premarketing clinical studies of Chantix, therefore, the safety and efficacy in this population has not been established.

Neuropsychiatric events were observed in patients with and without pre-existing psychiatric illness. There were reports of patients experiencing a worsening of psychiatric illness with Chantix. The prescribing information advises that all patients being treated with Chantix be observed for neuropsychiatric symptoms or worsening of pre-existing psychiatric disease.

Neuropsychiatric symptoms include behavioral changes, hostility, agitation, depressed mood, suicidal ideation or behaviors or attempted suicide. During postmarketing studies of Chantix for smoking cessation, neuropsychiatric symptoms, worsening of psychiatric illness and suicide were all been reported. The black box warning further recommends that the risks of Chantix should be weighed against the benefits. According to the black box warning for Zoloft, treatment with antidepressants may worsen depression and precipitate suicidal ideation and related behavior or unusual behavioral changes during initiation of therapy.

Whether or not this risk exists with prolonged treatment is still inclear. All patients treated with Zoloft should be appropriately monitored and closely observed for clinical worsening of depression, suicidality or unusual changes in behavior. Symptoms may include anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggression, impulsivity, restlessness, hypomania or mania, unusual changes in behavior or suicidal ideation or behaviors.

It is essential to consult with a physician regarding the risk of taking Zoloft and Chantix together, prior to beginning treatment. How can I lose weight on Zoloft? During controlled clinical trials of Zoloft sertraline , patients experienced a minimal one or two pound weight loss, on average.

Patients did not report significant weight gain or difficulty losing weight during clinical studies or postmarketing experience with Zoloft. However, Zoloft has been reported to cause changes in appetite and weight.

Zoloft is antidepressant that affects certain neurotransmitters in the brain, specifically serotonin. Zoloft is a potent and selective inhibitor of neuronal serotonin reuptake in the central nervous system and therefore categorized as a selective serotonin reuptake inhibitor SSRI. Zoloft is used for the treatment of post-traumatic stress disorder PTSD , panic disorder, premenstrual dysphoric disorder PMDD , anxiety disorders, obsessive-compulsive disorder OCD and major depressive disorder.

In general, irrespective of drug therapy, the safest and most effective method for long-term weight loss is proper diet and exercise. Eating a healthy, well-balanced diet full of fruits, vegetables and whole grains while limiting sugar, processed foods and alcohol typically people lose weight.

According to the prescribing information, patients being treated with Zoloft are already cautioned to avoid alcohol. According to the National Heart Lung and Blood Institute NHLBI , a part of the National Institutes of Health NIH , to lose weight it is essential for individuals to make lifestyle changes which focus on reducing calories from food and drink, a healthy eating plan and proper portion control.

Furthermore, the NHLBI outlines a healthy eating plan to control portion sizes and include fruits, vegetables, whole grains and fat-free or low-fat dairy products. A healthy eating plan should also include lean meats, poultry, fish, beans, eggs and nuts and be low in saturated fat, trans fat, cholesterol, sodium and added sugars.

To safely and effectively lose weight, in general and while taking Zoloft, individuals need to expend more calories than they take in. Essentially, reduce the daily caloric intake from food and beverages and increase calories burned through physical exercise.

An appropriate diet and exercise regimen should initially be under the guidance of a physician. How do I deal with Zoloft withdrawal?

During marketing of Zoloft sertraline , withdrawal symptoms were reported upon discontinuation of treatment. These adverse reactions were observed particularly upon abrupt discontinuation. However, the development of Zoloft withdrawal symptoms is possible even with gradual dose reduction, but this occurs less frequently. Reported Zoloft withdrawal symptoms included dysphoric mood, irritability, agitation, dizziness, sensory disturbances, anxiety, confusion, headache, lethargy, excessive emotional reactions and frequent changes in mood, insomnia and hypomania.

This occurrence is also referred to as selective serotonin reuptake inhibitor SSRI discontinuation syndrome and according to a review article from the Journal of Psychiatry and Neuroscience written in , may be relatively common.

To avoid unpleasant Zoloft withdrawal symptoms, patients are advised against abrupt discontinuation and are encouraged to gradually decrease the dose, under the supervision of a physician, when treatment is no longer required. It is important to monitor a patient for Zoloft withdrawal symptoms upon discontinuing treatment.

If unpleasant Zoloft withdrawal symptoms develop during a reduction in dosage, or upon discontinuation, and cannot be tolerated, it may require the physician to resume the previously prescribed dose and continue with a more conservative reduction in dosage going forward.

However, Zoloft withdrawal symptoms can recur upon later discontinuation. During clinical experience with Zoloft, most cases of adverse events, associated with discontinuation, were self-limiting and didn't require treatment. However, there were some reports of serious discontinuation symptoms. Although in some cases, patients may experience symptoms for several weeks, most patients experience a resolution of symptoms within approximately a week.

How do you take Zoloft for depression? According to clinical experience with Zoloft for depression, the relationship between the dose of medication and desired therapeutic effect for depression has not been established. However, patients were given doses ranging from 50 mg to mg daily during clinical trials.

When beginning treatment with Zoloft for depression, it is recommended that treatment be initiated at a dose of 50 mg administered once daily. Patients who appear to be unresponsive to the initial dose may be titrated up to a maximum dose of mg daily. Increases in dosage of Zoloft for depression should not occur at intervals of less than one week. Typically, patients need to take Zoloft for depression for several months or longer to achieve desired therapeutic outcomes.

It is essential that patients are periodically monitored and reassessed to determine if further treatment is required. When taking Zoloft for depression, each dose should be taken with a full glass of water and can be taken with or without food. Zoloft should be administered once daily, in the morning or evening. It is important to take each dose of Zoloft at the same time each day. When taking Zoloft for depression, it may take four weeks or longer to begin to feel an improvement in symptoms.

Do not stop taking Zoloft without consulting with a physician. Switching from other antidepressants or antiobsessional agents - There is limited controlled experience regarding the optimal timing of switching from other antidepressants or antiobsessional agents to Zoloft.

Care and prudent medical judgement should be exercised when switching, particularly from long-acting agents such as fluoxetine. The duration of washout period which should intervene before switching from one selective serotonin reuptake inhibitor SSRI to another has not been established.

Other interactions - Co-administration of Zoloft sertraline mg daily with diazepam or tolbutamide resulted in small, statistically significant changes in some pharmacokinetic parameters. Co-administration with cimetidine caused a substantial decrease in sertraline clearance.

The clinical significance of these changes is unknown. Warfarin - Co-administration of sertraline mg daily with warfarin resulted in a small but statistically significant increase in prothrombin time. Accordingly prothrombin time should be carefully monitored when Zoloft therapy is initiated or stopped.

No interactions reported with the following: Zoloft has no effect on the beta-adrenergic blocking ability of atenolol. No interaction of sertraline mg daily was observed with glibenclamide or digoxin. Lithium - In placebo-controlled trials in normal volunteers, the combined administration of lithium and Zoloft did not alter lithium pharmacokinetics.

It is recommended that plasma lithium levels be monitored following initiation of Zoloft therapy, so that appropriate adjustments to the lithium dose may be made if necessary. Co-administration with lithium may lead to a higher incidence of 5HT-associated side effects, resulting in an increase in tremor relative to placebo, indicating a possible pharmacodynamic interaction. Therefore, caution is recommended when co-administering sertraline with medications such as lithium, which may act via serotonergic mechanisms.

The apparent lack of clinically significant effects of the chronic administration of Zoloft mg daily on plasma concentrations of tolbutamide, phenytoin and warfarin suggests that Zoloft is not a clinically relevant inhibitor of CYP 2C9. The apparent lack of clinically significant effects of the chronic administration of Zoloft mg daily on plasma concentrations of diazepam suggests that Zoloft is not a clinically relevant inhibitor of CYP 2C Serious sequelae have not been reported following overdoses of sertraline alone of up to 6 g.

Therefore, any overdosage should be treated aggressively. No specific therapy is recommended and there are no specific antidotes to sertraline. Establish and maintain an airway, ensure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, a cathartic, may be as, or more, effective than emesis or lavage, and should be considered in treating overdosage. Monitoring of cardiac and vital signs is recommended, along with general symptomatic and supportive measures.

Zoloft Side Effects

To treat obsessive-compulsive disorder with Zoloft, in both adults and 50mg pediatric population, the daily dose should be administered once daily, either in the morning or evening. According to the National Heart Lung and Zoloft Institute NHLBIa part of the National Institutes of Health NIHto lose weight it is essential for individuals to make lifestyle changes which focus on reducing calories from food and drink, a healthy eating plan and proper portion control. Fatigue, hot flushes, fever, back pain Metabolic and nutritional symptoms: As always, talk with your health care provider regarding concerns you have about your medication and possible side effects. I am effects on Zoloft, and, would appreciate any valid information you can give me on it. Please talk with your health care provider regarding your options in treatment. The following website discusses many aspects of the drug: My doctor agrees with the idea but said I must not stop abruptly. I have been diagnosed with bipolar disorder and have been put on Zoloft, effects of zoloft 50mg. Zoloft sertraline is a pregnancy category C medicine, meaning that 50mg medication could potentially cause harm to your unborn child. If unpleasant Zoloft withdrawal symptoms develop during a reduction in dosage, or upon discontinuation, and cannot be tolerated, it may require the physician to resume the previously prescribed dose and continue with a more conservative reduction in dosage going forward. Zoloft sertraline is a selective serotonin reuptake inhibitor SSRI antidepressant. Zoloft sertraline may be taken with our without food and should be taken with water. Talk to your doctor about your concerns with Zoloft and alcohol. Do not take any over the counter medications without first consulting with a health care provider as some over the counter products contain alcohol or other ingredients that may zoloft interact with Zoloft, including many cough, cold effects flu products and pain relievers. Suicide ideation was reported by 3 sertraline-treated patients and no placebo-treated patients; however the difference was not statistically significant. The average terminal plasma half-life is about 26 hours, effects of zoloft 50mg.

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