This is a popular bisphosphonate drug widely prescribed by doctors and advertised on TV and other media outlets. Marketing ads for this drug offer no information whatsoever on what bisphosphonates are really made of, and for a good reason. It was published in the prestigious Endocrine Reviews in the year Fleisch was a Swiss pioneer researcher on metabolic bone diseases whose work led to the discovery of bisphoshponates as osteoporosis drugs.
Their ability to inhibit calcium carbonate precipitation, similar to polyphosphates, was put to good use in the prevention of scaling. Only in the past three decades have bisphosphonates been developed as drugs for use in various diseases of bone, tooth, and calcium metabolism. Obviously, that is not the case because thanks to several not-so-coincidental sequence of events, bisphosphonate drugs became instant best-sellers, raking billions of dollars to their manufacturers.
The story of an osteoporosis drug as told by Mr. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Click here to view a more detailed list of Fosavance side effects. Then resume taking your weekly dose on your originally scheduled day of the week. Do not take two doses on the same day. See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Vitamin D3 is very similar to calcitriol. Do not use medications containing calcitriol while using vitamin D3. Growing evidence has now linked the drugs to a long list of worrisome side effects. Those concerns have recently taken on added urgency as many doctors have started prescribing bisphosphonates not just for people with outright osteoporosis but also for those with osteopenia, or pre-osteoporosis, even though it's less clear that the drugs are effective for this less serious but more common condition.
Here's a rundown on the benefits and risks of the drugs, some guidelines to help you decide when these drugs might be worthwhile, and some nondrug alternatives that may reduce or even eliminate your need for medication.
Modest benefits Bisphosphonates are a proven remedy for preventing fractures in people with osteoporosis, but that benefit is relatively modest. A pivotal study, for example, found that Other analysis found that 22 women with a history of an osteoporosis-related fracture would need to be treated for three years to prevent another one.
At the same time, women with severe bone loss would need to be treated for three years to prevent one hip fracture. For people with bone loss from the long-term use of corticosteroids such as prednisone, bisphosphonate therapy improves bone-mineral density in the lower spine by about 4 percent. But it doesn't cut the number of spinal fractures, according to a comprehensive review by the Cochrane Collaboration.
It is even less clear that the benefits of using these drugs to treat women with osteopenia are worth the cost and the potential side effects. Growing risks Those modest benefits need to be balanced with the risks, which have been increasingly evident since alendronate was introduced more than 14 years ago. Early studies of the drug, for example, suggested that it was no more likely than a sugar pill to cause gastrointestinal problems. But within a year of its introduction, reports of adverse events, including injuries to the stomach and esophagus, began pouring in.
That prompted Merck, the manufacturer, to issue revised labeling for the drug. And that was just the start. Alendronate has received an eyebrow-raising 16 FDA-mandated changes to its label related to updates on its safety and side effects. Some of those problems—throat or chest pain, difficulty swallowing, and heartburn—can be managed by taking certain precautions. But research has increasingly linked bisphosphonates to less common but more serious and long-lasting problems, including an abnormal heart rhythm atrial fibrillation ; incapacitating bone, joint, and muscle pain; and bone loss in the jaw osteonecrosis.
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