Zyprexa 30mg - A review of olanzapine-associated toxicity and fatality in overdose

Bipolar I Disorder Manic or Mixed Episodes Adults Dose Selection for Monotherapy — Oral olanzapine should be administered zyprexa a once-a-day schedule without regard to meals, zyprexa 30mg, generally beginning with 10 or 15 mg.

Dosage adjustments, if indicated, should 30mg occur at intervals of not less than 24 hours, reflecting the procedures in the placebo-controlled trials.

Zyprexa Dosage

Dose Selection for Adjunctive Treatment — When administered as adjunctive treatment to lithium or valproate, oral olanzapine zyprexa should generally begin with 10 mg once-a-day without regard to meals. Efficacy in adolescents with bipolar I disorder 30mg or mixed episodes was demonstrated based on a flexible dose range of 2. Consequently, patients should be evaluated carefully for a history of drug abuse, and such patients should be observed closely 30mg signs of misuse or abuse of olanzapine e, zyprexa 30mg.

Vital signs were usually within normal limits following overdoses. In postmarketing reports of overdose with olanzapine alone, symptoms have been reported in the majority zyprexa cases, zyprexa 30mg, zyprexa 30mg. Among less commonly reported symptoms were the following potentially medically zyprexa reactions: Eli Lilly and Company has received reports of fatality in association with overdose of olanzapine alone.

Management of Overdose For current information on the management of Zyprexa 30mg overdose, contact a certified poison control center or www, zyprexa 30mg. The possibility of multiple drug 30mg should be considered, zyprexa 30mg. zyprexa

Is 30mg of zyprexa considered an overdose?

In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation, which may include intubation. Gastric lavage after intubation, if patient is unconscious and administration of activated charcoal together with a laxative should be considered.

The possibility of obtundation, zyprexa 30mg, seizures, or dystonic reaction of the head and neck following overdose may create zyprexa risk of aspiration with induced emesis. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to 30mg possible arrhythmias. There is no specific antidote to olanzapine.

Therefore, appropriate supportive measures should be initiated.

A review of olanzapine-associated toxicity and fatality in overdose

Do not use epinephrine, dopamine, or zyprexa sympathomimetics with beta-agonist activity, since beta stimulation may worsen hypotension in the setting of olanzapine-induced alpha blockade. Close medical supervision and monitoring should continue until the patient recovers. For specific information about overdosage with lithium or valproate, refer to the Overdosage section of the package inserts for these products.

For specific 30mg about overdosage with olanzapine and fluoxetine in combination, refer to the Overdosage section of the Symbyax package insert, zyprexa 30mg. Zyprexa Description Zyprexa olanzapine is an atypical antipsychotic that belongs to the thienobenzodiazepine class. The chemical designation is 2-methyl 4-methylpiperazinyl H-thieno[2,3-b] [1,5]benzodiazepine.

The molecular formula is C17H20N4S, which corresponds to a molecular zyprexa of The chemical structure is: There are some case reports of olanzapine-induced diabetic ketoacidosis, zyprexa 30mg. 30mg toxicology[ edit ] Olanzapine has demonstrated carcinogenic effects in multiple studies when exposed chronically to female mice and rats, but not male mice and rats, zyprexa 30mg.

The tumors found were in either the liver 30mg mammary glands of zyprexa animals.

The entire label should be read to gain a complete understanding of the safety profile of olanzapine. The prescriber 30mg be aware that the figures in the tables and tabulations zyprexa be used to predict the incidence of side effects in the course of usual medical practice where patient characteristics and other factors differ from those that prevailed in the clinical trials.

Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. See also Notes section.

Olanzapine may rarely cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. This medication zyprexa increase a certain natural substance prolactin made by your body.

Dosage for Injectable Forms of Zyprexa Immediate-release Zyprexa injection is given to patients exhibiting 30mg due to bipolar disorder or schizophrenia. The usual dose ranges from 2.

Extended-release Zyprexa injection e, zyprexa 30mg.

Cardiovascular disease and diabetes were reported in 1 case 19and obesity, asthma and breast carcinoma 30mg reported zyprexa 1 case The Canadian Adverse Drug Reaction Monitoring Program Newsletter of July 27 advised that olanzapine was reported as a suspected drug in 22 deaths, including 8 involving suicide or overdose and 14 due to a variety of causes e.

Malignant hyperpyrexia was reported as the cause of death in an overdose of olanzapine mg and diphenhydramine 20 mg, zyprexa 30mg. The cause of death was not determined in 1 case in which olanzapine was added to an existing regimen of loxapine, nor in 1 case of a patient with hypertension, chronic obstructive pulmonary disease, adrenal insufficiency and irritable bowel syndrome with a kg weight gain in 2 years who zyprexa taking multiple medications, zyprexa 30mg.

30mg

Olanzapine

Of note, all information provided by the Health Product Safety Information Division is subject to 30mg caveat that data are unpublished and received from a variety of sources; thus, zyprexa 30mg, cause and effect relations have not been established.

From medical examiners' reports and the Canadian Adverse 30mg Reaction Monitoring Program, there were 16 cases in which olanzapine was identified as the principal cause of toxicity or contributory in 30mg toxicity. Discussion Given the limitations of autopsy material, a causal relation cannot be inferred from the data presented. Nonetheless, zyprexa 30mg, there are potentially 29 cases in which acute olanzapine toxicity appears to have contributed 30mg death, zyprexa 30mg.

These numbers are definitely small when zyprexa with the number of prescriptions for olanzapine, zyprexa it is likely that data for many cases not just involving 30mg are not readily accessible and therefore represent underestimates of zyprexa total numbers of zyprexa drug-related toxicity cases. The findings have clinical relevance, but zyprexa significance, zyprexa 30mg, particularly for olanzapine, zyprexa unclear given the lack of comparative data at this point.

The inherent difficulties in collecting these data include lack of computerized databases, toxicology findings not systematically recorded by drug, and cause of death not recorded as an overdose, zyprexa 30mg. Interpretation of postmortem concentrations of new drugs is particularly difficult because no postmortem database exists and perimortem details are usually unavailable, zyprexa 30mg.

Postmortem concentrations are usually zyprexa with therapeutic 30mg pharmacokinetic data because this is the zyprexa information available and, consequently, high concentrations are interpreted as consistent with overdose, zyprexa 30mg.

Furthermore, the number of cases detected is not only a function of the frequency of drug use in that particular jurisdiction 30mg also of the analytical procedures used by the investigating laboratory, zyprexa 30mg. However, risperidone and pimozide are not detected 30mg the screening procedures used 30mg most postmortem toxicology laboratories, zyprexa 30mg, and their overdose occurrence is thus likely to be under-reported.

zyprexa

Zyprexa and Risperidone make it harder to function

The relative safety of the atypical antipsychotics has been comprehensively reviewed elsewhere. Also, a review of inquiries to the UK National Poisons Information Service over 9 months revealed no fatalities 30mg overdoses of atypical antipsychotics. However, zyprexa 30mg, the outcome 30mg treated overdoses in hospital settings likely differs from outcomes for individuals who do not receive active intervention, and, as the authors comment, patients who zyprexa outside of zyprexa are unlikely to be revealed by inquiries to a poison centre, zyprexa 30mg.

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