The 40 mg tablets are yellow, marked OC on one side and 40 on the other, percocetmg 15. The 60 mg tablets are red, percocetmg 15, marked OC on one side and 60 on the other, percocetmg 15. The 80 mg tablets are green, marked OC on one side and 80 on the other. The mg tablets are purple, marked OC on percocetmg side and on the other. For the treatment of severe pain requiring the use of a strong opioid.
OxyContin tablets should be taken at hourly intervals. The dosage is dependent on the severity of the pain, and percocetmg patient's previous history of analgesic requirements. OxyContin is not intended for use as a prn analgesic, percocetmg 15.
Increasing severity of pain will require an increased dosage of OxyContin tablets, using the 5 mg, 10 percocetmg, 20 mg, 40 mg or 80 mg tablet strengths, either alone or in combination, percocetmg achieve pain relief. The correct dosage for any individual patient is that which controls the pain and is well tolerated for a full 12 hours. Patients should be titrated to pain relief unless unmanageable adverse drug reactions prevent this, percocetmg 15.
The need for escape medication more than twice a day indicates that the dosage of OxyContin tablets should be increased, percocetmg 15. Some patients may benefit percocetmg a starting dose of 5 mg to percocetmg the incidence of side effects.
The dose should then be carefully titrated, as frequently as once a day if necessary, to achieve pain relief, percocetmg 15.
For the majority of patients, the maximum dose is mg hourly. However, a few patients may require higher doses. Doses in excess of mg daily have been recorded. Conversion from oral morphine: Patients receiving oral morphine before OxyContin therapy should have their daily dose based on the following ratio: It must be emphasised that this is a guide to the dose of OxyContin notice priligy 30mg required.
Percocetmg variability requires that each patient is carefully percocetmg to the appropriate dose. A dose adjustment is not usually necessary in elderly patients, percocetmg 15. Controlled pharmacokinetic studies in elderly patients aged over 65 percocetmg have shown that, compared with younger adults, the clearance of oxycodone is only slightly reduced, percocetmg 15. No untoward adverse drug reactions were seen based on age, percocetmg 15, therefore adult doses and dosage intervals are appropriate, percocetmg 15.
Paediatric population OxyContin should not be used in patients under 18 years of age, percocetmg 15. Patients with renal or hepatic impairment: The plasma concentration in this population may be increased. The dose initiation should follow a conservative approach in these patients, percocetmg 15.
Use in non-malignant pain: Opioids are not first-line therapy for chronic non-malignant pain, nor are they recommended as the only treatment. Types of chronic pain which have been shown to be percocetmg by strong opioids include chronic osteoarthritic pain and intervertebral disc disease. The need for continued treatment in non-malignant pain should be assessed at regular intervals. Method of administration OxyContin tablets are for oral use. OxyContin tablets must be swallowed whole and not broken, percocetmg 15, chewed or crushed.
Duration of treatment Oxycodone should not be used for longer than necessary. Discontinuation of treatment When a patient no longer requires therapy with oxycodone, it may be percocetmg to taper the dose gradually to prevent symptoms of withdrawal. Oxycodone must not be used in any situation where opioids are contraindicated: Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Opioid analgesics should be used with caution when combined with CNS depressant drugs. Oxycodone may aggravate convulsions in patients with convulsive disorders, and all opioids may induce or aggravate seizures in some clinical settings, percocetmg 15.
If Roxicodone is abruptly discontinued in a physically dependent patient, an abstinence syndrome may occur. Roxicodone may cause spasm of the sphincter of Oddi. Common adverse reactions include: Oxycodone has been detected in breast milk. Withdrawal symptoms can occur in breast-feeding infants when maternal administration of an opioid analgesic is stopped. The safety and efficacy of oxycodone in pediatric percocetmg have not been evaluated. Dose initiation should be conservative in patients with renal or hepatic impairment.
The possible effects on male or female fertility have not been studied in animals. Oxycodone hydrochloride was genotoxic in an in vitro mouse lymphoma assay in the presence of metabolic activation. There was no evidence of genotoxic potential in an in vitro bacterial reverse mutation assay Salmonella typhimurium and Escherichia coli or in an assay for chromosomal aberrations in vivo mouse bone marrow micronucleus assay.
There are no adequate and well controlled studies of oxycodone in pregnant women. Occasionally, opioid analgesics may prolong labor through actions which temporarily reduce the strength, duration and frequency of uterine contractions.
Neonates, whose mothers received opioid analgesics during labor, should be observed closely for signs of respiratory depression. A specific narcotic antagonist, percocetmg 15, naloxoneshould be available for percocetmg of narcotic-induced respiratory depression in the neonate.
Nursing Mothers Oxycodone has been detected in breast milk. Withdrawal symptoms can occur in breast-feeding infants when maternal administration of an opioid analgesic is stopped. Pediatric Use The safety and efficacy of oxycodone in pediatric patients have percocetmg been evaluated.
No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Hepatic Impairment Since oxycodone is extensively metabolized, its clearance may decrease in hepatic failure patients. Dose initiation in patients with hepatic impairment should follow a conservative approach.
Dosages should be adjusted according to the clinical situation.
Renal Impairment Published data reported that elimination of oxycodone was impaired in end-stage renal failure. Mean elimination half-life was prolonged in uremic patients due to increased volume of distribution and reduced clearance. Dose initiation should follow a conservative approach. Percocetmg patient using this drug should be cautioned accordingly. Supportive measures including oxygen and vasopressors should be employed in the management of circulatory shock and pulmonary edema accompanying overdose as indicated.
Cardiac arrest or arrhythmias may require cardiac massage or defibrillation, percocetmg 15. The narcotic antagonists, naloxone or nalmefene, are specific antidotes for opioid overdose, percocetmg 15. If needed the appropriate dose of naloxone hydrochloride or nalmefene should be administered simultaneously with efforts at respiratory resuscitation see package insert for each drug for the details.
Since the duration of action of oxycodone may exceed that of the antagonistthe patient should be kept under continued surveillance and repeated doses of the antagonist should be administered as needed to maintain adequate respiration.
Gastric emptying may be useful in removing unabsorbed drug. Opioid antagonists should be administered cautiously to persons who are suspected to be physically dependent on any opioid agonistincluding oxycodone see Opioid-Tolerant Percocetmg. Opioid-Tolerant Individuals In an individual physically dependent on opioids, administration of a usual dose of antagonist will precipitate an acute withdrawal, percocetmg 15.
The severity of the withdrawal syndrome produced will depend on the degree of physical dependence and the dose of the antagonist administered. Use of an opioid antagonist should be reserved for cases where such treatment is clearly needed. If it is necessary to treat serious respiratory depression percocetmg the physically dependent patient, administration of the antagonist should be begun with care and by titration with smaller than usual doses.
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