Nitroglycerin tablets 0.4mg - Nitrostat Sublingual : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
If one elects to use nitroglycerin in these conditions, careful clinical or 0.4mg monitoring must be used because of the possibility of hypotension and tachycardia, nitroglycerin tablets 0.4mg. Only the smallest dose required for effective relief of the acute 0.4mg attack should be used, nitroglycerin tablets 0.4mg. Excessive use may lead to the development of tolerance.
Nitrostat tablets are intended for sublingual or buccal tablet and should not be swallowed. Severe hypotension, particularly with upright posture, may occur with small doses of nitroglycerin. This drug should therefore be used with caution in patients who may be volume-depleted or who, for whatever nitroglycerin, are already hypotensive.
Hypotension induced by nitroglycerin may be accompanied by paradoxical bradycardia and increased angina pectoris. Nitrate tablet may aggravate the angina caused by hypertrophic cardiomyopathy.
As tolerance to other forms of nitroglycerin develops, the effects of sublingual nitroglycerin on exercise tolerance, although still observable, is blunted. In industrial workers who have had long-term nitroglycerin to unknown presumably high doses of organic nitrates, tolerance rarely occurs.
0.4mg pain, acute myocardial infarction, and even sudden death have occurred during temporary withdrawal of nitrates from these workers, demonstrating the existence of true physical dependence. Several clinical trials of nitroglycerin patches or infusions in patients with angina pectoris have evaluated regimens that incorporated a to hour nitrate free interval, nitroglycerin tablets 0.4mg.
In 0.4mg of these trials, an increase in the frequency of anginal attacks during the nitrate free interval was observed in a small number of patients. In one trial, patients had decreased exercise tolerance at the end of the nitrate interval. Hemodynamic rebound has been observed only rarely; on the other hand, few studies were so designed that rebound, if it had occurred, would have been detected. Nitrate tolerance as a result of sublingual nitroglycerin administration is probably possible, but only in patients who maintain high continuous nitrate levels for more than 10 or 12 nitroglycerins daily.
Such use of sublingual nitroglycerin would entail administration of scores of tablets daily and is not recommended. The drug should be discontinued if blurring of vision or drying of the mouth occurs. Excessive dosage of nitroglycerin may produce severe headaches. Nitrostat is a sublingual tablet and should not be chewed, nitroglycerin tablets 0.4mg, crushed, or swallowed.
If possible, patients should sit down when taking Nitrostat tablets and should use caution when returning to a standing position. This eliminates the possibility of tablet due to lightheadedness or dizziness. One tablet should be dissolved under the tongue or in the buccal pouch at the first sign of an acute anginal attack.
The dose may be repeated approximately every 5 minutes until relief is obtained. If chest pain persists after a total of 3 tablets in a minute period, or if the pain is different than is typically experienced, nitroglycerin tablets 0.4mg, prompt medical attention is recommended.
Nitrostat may be used prophylactically 5 to 10 minutes prior to engaging in activities that might precipitate an acute attack. Nitroglycerin may produce a burning or tingling sensation when administered sublingually; however, the tablet to produce a burning or tingling sensation should not be considered a reliable method for determining the potency of the tablets.
Headaches can sometimes accompany treatment with nitroglycerin. In patients who get these headaches, the headaches may be a marker of the activity of the drug.
Treatment with nitroglycerin may be associated with lightheadedness upon standing, especially just after rising from a recumbent or seated position.
This effect may be more frequent in patients who have also consumed tablet. Nitroglycerin should be kept in the original glass container and must be tightly capped nitroglycerin each use to prevent loss of tablet potency. Patients receiving antihypertensive drugs, beta-adrenergic blockers, or phenothiazines and nitrates should be observed for possible additive hypotensive preise levitra 10. Marked orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used 0.4mg.
Concomitant use of nitrates and alcohol may cause hypotension. The vasodilatory and hemodynamic effects of nitroglycerin may be enhanced by concomitant administration of aspirin.
Intravenous administration of nitroglycerin decreases the thrombolytic effect of alteplase. Therefore, caution should be observed in patients receiving sublingual tablet during alteplase therapy, nitroglycerin tablets 0.4mg.
Intravenous nitroglycerin reduces the anticoagulant effect of 0.4mg and activated partial thromboplastin times APTT should be monitored in patients receiving heparin and intravenous nitroglycerin. It is not known if this effect occurs following single sublingual nitroglycerin doses.
Nitroglycerin Sublingual Tablets
Tricyclic antidepressants amitriptyline, desipramine, doxepin, others and anticholinergic drugs may cause dry mouth and diminished salivary secretions. This may make dissolution of sublingual nitroglycerin difficult. Increasing salivation with chewing gum or artificial saliva products may prove useful in aiding dissolution of sublingual nitroglycerin, nitroglycerin tablets 0.4mg.
Oral administration of nitroglycerin markedly decreases the first-pass metabolism of dihydroergotamine and subsequently increases its oral bioavailability.
Ergotamine is known to precipitate angina pectoris. Therefore, patients receiving sublingual nitroglycerin should avoid ergotamine and related drugs or be monitored for symptoms of ergotism if this is not possible. Administration of nitroglycerin is contraindicated in patients who are using PDE-5 inhibitors e.
These compounds have been shown to potentiate the hypotensive effects of organic nitrates. A decrease in therapeutic effect of acyclovir tablet 800mg nitroglycerin may result from use of long-acting nitrates, nitroglycerin tablets 0.4mg.
Nitrates may interfere nitroglycerin the Zlatkis-Zak tablet reaction, causing 0.4mg false report of decreased serum cholesterol. Carcinogenesis, Mutagenesis, Impairment of Fertility: Animal 0.4mg studies with sublingually administered nitroglycerin have not been performed, nitroglycerin tablets 0.4mg. Nitroglycerin was weakly mutagenic in Ames tests performed in 2 different laboratories. The high dose was associated with decreased feed intake and body weight gain in both sexes at all matings.
No specific effect on the 0.4mg of the F0 generation was seen. Infertility noted in subsequent generations, however, was attributed to increased interstitial tablet tissue and aspermatogenesis in the high-dose tablets.
In this 3-generation study, there was no clear evidence of teratogenicity, nitroglycerin tablets 0.4mg. Animal nitroglycerin and teratogenicity studies have not been conducted with nitroglycerin sublingual tablets.
No toxic effects on dams or fetuses were seen at any dose tested. There are no adequate and well-controlled studies in pregnant women, nitroglycerin tablets 0.4mg. Nitroglycerin should be given to a pregnant woman only if clearly needed.
It is not known tablet nitroglycerin is excreted in human milk. Because many drugs are excreted in human milk, 0.4mg should be exercised when nitroglycerin is administered to a nursing woman. Do not shake the container. If this is a new bottle or container, prime the pump before use by releasing a nitroglycerin spray.
This must be done 5 or 10 times into the air away from your face and other people. If this is an old bottle and you have not used it for more than 6 weeks, you must prime it again with 1 or 2 test sprays, nitroglycerin tablets 0.4mg. If it is not 0.4mg used within 3 tablets, prime it up to 5 sprays. Hold the container upright with your forefinger on top of the grooved button. Open your mouth and bring the container as close to it as possible, nitroglycerin tablets 0.4mg.
Press the button firmly with the forefinger to release the spray 1 or 2 times onto or nitroglycerin the tongue. Do not inhale or breathe in the spray. Release the button and close your mouth, but do not swallow right away.
Do not spit out the spray or rinse your mouth for at least 5 to 10 minutes. If you need a third spray, you must wait 5 minutes after the second spray.
Use exactly the same steps you used for the first spray. No more than 3 sprays should be given within 15 minutes, nitroglycerin tablets 0.4mg. Replace the cover after using the medicine. Always place the spray bottle in an upright position if not in use. If the fluid reaches the top or middle of the hole on the side of container, this is an indicator that 0.4mg must get a refill.
Do not use the spray near heat, an open flame, or while smoking, nitroglycerin tablets 0.4mg. Dosing The tablet of this medicine will be different for different patients.
Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, nitroglycerin tablets 0.4mg, do not change it unless your doctor tells you to do so. The amount of nitroglycerin that you take depends on the strength of 0.4mg medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the nitroglycerin depend on the nitroglycerin problem for which you are using the medicine.
For prevention or tablet of angina: For oral dosage form extended-release capsules: Your doctor may increase your dose 0.4mg needed, nitroglycerin tablets 0.4mg. Children—Use and dose must be determined by your doctor. For sublingual dosage form powder: Adults—1 or 2 packets placed under the tablet at the first sign of an angina attack.
For sublingual dosage form spray: Adults—1 or 2 nitroglycerins on or under the tongue at the first sign of an chest pain. Sprays may be repeated every 5 minutes as needed.
You must wait 5 minutes before administering a third spray if 2 sprays are used initially. Do not use more than 3 sprays in 15 minutes. To prevent angina from exercise or stress, use 1 or 2 tobradex for sore eyes price 5 to 10 minutes before the activity. For sublingual dosage form tablets: Adults—1 tablet placed under the tongue or between the cheek and gum at the first sign of an angina attack.
Do not take more than 3 tablets in 15 minutes, nitroglycerin tablets 0.4mg. To prevent angina from exercise or stress, use 1 tablet 5 to 10 minutes before the activity.
Missed Dose If you miss a dose of this medicine, nitroglycerin tablets 0.4mg, take it as soon as possible. However, if it is almost nitroglycerin for your next dose, skip the missed dose and go 0.4mg to your regular dosing tablet.
Do not double doses. Storage Keep out of the reach of children. Do not tablet outdated medicine or medicine no longer needed, nitroglycerin tablets 0.4mg. Ask your healthcare professional 0.4mg you should dispose of any medicine you do not use.
Store the extended-release capsules in a closed container at room temperature, away from heat, moisture, nitroglycerin tablets 0.4mg, and direct light. Store the sublingual tablet at room temperature, away from heat, moisture, and direct light. Sublingual tablets should be kept in the original 0.4mg bottle. Screw the cap on tightly after each use and store the bottle at room temperature, away from nitroglycerin, moisture, and direct light.
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