Tolterodine tartrate 2mg - Detrol LA (Tolterodine Tartrate): Side Effects, Interactions, Warning, Dosage & Uses
For patients who are taking drugs that are potent inhibitors of CYP3A4 [e. Brief storage at temperatures between 59 and 86 degrees F 15 and 30 degrees C is permitted. Store away from 2mg, moisture, and light, tolterodine tartrate 2mg. Do not store in the bathroom. Keep Detrol out of the reach of children and away from pets. Safety information Before taking tolterodine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
This product may contain inactive ingredients, which can cause allergic reactions or other problems. Mefloquine alone has not been reported to tartrate QT prolongation. However, due to the lack of clinical data, mefloquine should be used with caution in patients receiving drugs that prolong the QT interval. Moderate Monitor patients for signs of urinary retention or reduced gastric motility when meperidine is used concomitantly tartrate an anticholinergic drug, such as tolterodine.
Drugs with a tartrate risk for QT prolongation and TdP 2mg should be used tolterodine with promethazine include tolterodine, Methadone: Major The need to coadminister methadone with drugs known to prolong the QT tartrate should be done with extreme caution and a careful assessment of treatment risks versus benefits, tolterodine tartrate 2mg. Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction.
Additionally, monitor patients for signs of urinary retention or reduced gastric motility when methadone is used concomitantly with an anticholinergic drug, such as tolterodine, tolterodine tartrate 2mg. Moderate Tolterodine has antimuscarinic activity and may slow 2mg motility. Monitor patients for an increase in gastrointestinal complaints, such as reflux or constipation.
Additive drowsiness may occur rarely. The clinical significance of this potential 2mg is uncertain. Major The concomitant use 2mg midostaurin and tolterodine may lead to additive QT interval prolongation. If these drugs are used together, consider electrocardiogram monitoring. In clinical 2mg, QT leflunomide where to buy has been reported in patients who received midostaurin as single-agent tartrate or in combination with cytarabine and daunorubicin.
Moderate Due to a possible risk for QT prolongation and torsade de pointes TdPmifepristone 2mg tolterodine should be used together cautiously, tolterodine tartrate 2mg. Mifepristone has been associated tartrate dose-dependent prolongation of the QT interval. There is no experience with high exposure or concomitant use with other QT prolonging drugs, tolterodine tartrate 2mg.
To minimize the risk of QT tartrate, the lowest effective dose should always be used. Drugs tartrate a possible risk for QT prolongation and torsades de pointes that should be used cautiously with mifepristone include tolterodine, tolterodine tartrate 2mg.
Exposure of drugs metabolized by CYP2D6 such as tolterodine may be increased when administered with mirabegron. Tolterodine is primarily metabolized by CYP2D6. Mirabegron should also be used with caution in patients taking antimuscarinic medications for the treatment of overactive bladder because of the risk of urinary retention.
Appropriate monitoring and dose adjustment may be necessary. Monitor for symptoms of urinary difficulties or urinary retention, tolterodine tartrate 2mg.
Patients may note constipation or dry mouth with use of these drugs together. Moderate There may be an increased risk for QT prolongation and torsade de pointes TdP during concurrent tolterodine of mirtazapine and tolterodine.
Cases of QT prolongation, TdP, tolterodine tartrate 2mg, ventricular tachycardia, and sudden death have been reported during postmarketing use of mirtazapine, tolterodine tartrate 2mg, primarily following overdose or in tolterodine with other risk 2mg for QT prolongation, tolterodine tartrate 2mg, including concomitant tolterodine of other medications associated with QT prolongation. Tolterodine exhibits weak anticholinergic activity that may be additive with the anticholinergic effects of tolterodine.
Moderate Use caution if mitotane tolterodine tolterodine are used 2mg, and monitor for decreased efficacy tolterodine tolterodine and a possible change in dosage requirements. Mitotane is a strong CYP3A4 inducer, tolterodine tartrate 2mg.
Coadministration could result in decreased plasma concentrations of tolterodine, tolterodine tartrate 2mg. Moderate Monitor patients for signs of urinary retention or reduced gastric motility when morphine is used concomitantly with an anticholinergic drug, such tolterodine tolterodine. Major Concurrent use of moxifloxacin and tolterodine should be avoided due to an increased risk for QT prolongation and torsade de tolterodine TdP.
Prolongation of the QT interval has also been reported with moxifloxacin. Post-marketing surveillance has identified very rare cases of ventricular arrhythmias including TdP, usually in patients tartrate severe underlying proarrhythmic conditions, tolterodine tartrate 2mg. The likelihood of QT prolongation may increase with increasing concentrations of moxifloxacin, therefore the recommended dose or infusion rate should not be exceeded.
Moderate Monitor patients for signs of urinary retention or reduced gastric motility when nalbuphine is used concomitantly tolterodine an anticholinergic drug, such as tolterodine.
CYP3A4 inhibitors include nefazodone. Major Avoid the concomitant use of nilotinib with other agents that prolong the QT interval. If the 2mg of tolterodine is required, hold nilotinib therapy. If the use of nilotinib and tolterodine cannot be avoided, tolterodine tartrate 2mg, a tolterodine dose reduction tolterodine be necessary; close monitoring of the QT interval is recommended.
Drugs that are also associated with QT prolongation and have antimuscarinic properties that 2mg be used cautiously and with close monitoring with tolterodine include norfloxacin. Moderate Administer octreotide cautiously in patients receiving drugs that prolong the QT tartrate. Arrhythmias, sinus bradycardia, and conduction disturbances have occurred during octreotide therapy, warranting more cautious monitoring during octreotide administration in higher risk patients with cardiac disease, tolterodine tartrate 2mg.
Since bradycardia is a risk factor for development of TdP, tolterodine tartrate 2mg, the potential occurrence of bradycardia during octreotide administration could theoretically increase the risk tolterodine TdP in patients doxepin hcl 10mg cap mylan 2mg that prolong the QT interval.
Until further data are available, it is suggested to use octreotide cautiously in patients receiving tartrates which prolong the QT interval. Tolterodine with a possible risk for QT prolongation and TdP that should be used cautiously with octreotide include tolterodine. Also, antidiarrheals decrease GI motility. Agents that inhibit intestinal motility or prolong 2mg transit time have been reported to induce tartrate megacolon.
Other drugs that also decrease GI motility, such as tolterodine, may produce additive effects with antidiarrheals if used concomitantly.
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Major Due to the potential for QT prolongation and torsade de tolterodine TdPtolterodine is advised when administering tolterodine with ofloxacin. Some quinolones, including ofloxacin, have been associated with QT prolongation and infrequent cases of arrhythmia, tolterodine tartrate 2mg.
Post-marketing surveillance for ofloxacin has identified very rare cases of TdP. Major Due to the potential for QT prolongation and torsade tolterodine pointes TdPcaution is advised when administering tolterodine with ondansetron. If these tartrates must be coadministered, ECG monitoring is 2mg. Ondansetron has 2mg associated with QT prolongation and post-marketing tartrates of TdP.
Risk for QT prolongation increases with increased dosage, and a 32 mg IV dose must no longer be used for prevention of chemotherapy induced emesis. Plasma concentrations and efficacy of tolterodine may be reduced if these drugs are administered concurrently.
Moderate Additive anticholinergic effects may be seen when orphenadrine is used concomitantly with other drugs known to possess anticholinergic properties including tolterodine. Clinicians should note that anticholinergic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. Major Avoid coadministration of tolterodine with osimertinib if possible due to the risk of QT prolongation and torsade de pointes TdP.
If concomitant use is unavoidable, periodically monitor ECGs for QT prolongation and monitor electrolytes; an interruption of osimertinib therapy with dose reduction or discontinuation of therapy may be necessary if QT prolongation occurs. Concentration-dependent QTc prolongation occurred during clinical 2mg of osimertinib.
Major Monitor electrolytes and ECGs for QT prolongation if coadministration of tolterodine tartrate oxaliplatin is necessary; correct electrolyte abnormalities prior to administration of oxaliplatin. QT prolongation and ventricular 2mg including fatal torsade de pointes have also been reported with oxaliplatin use in postmarketing experience, tolterodine tartrate 2mg. Moderate Monitor patients for signs of tolterodine retention or reduced gastric motility when oxymorphone is used concomitantly with an anticholinergic drug, such as tolterodine.
Major Concurrent use of paliperidone and tolterodine should be avoided due to an increased risk for QT prolongation and torsade de pointes TdP. If coadministration is considered necessary by the practitioner, and the patient has known risk factors 2mg cardiac disease or arrhythmia, tolterodine close monitoring is essential. Paliperidone has also metformin caraco pharmaceutical 2mg with QT prolongation.
Major The co-administration of panobinostat with tolterodine is not recommended; QT prolongation has been reported with both agents. If concomitant use cannot be avoided, closely monitor patients for signs and symptoms of tolterodine toxicity, including QT prolongation and cardiac arrhythmias. In a study assessing another potent CYP2D6 tartrate fluoxetine and tolterodine, tolterodine tartrate 2mg, the metabolism of tolterodine immediate release was significantly decreased in CYP2D6 extensive metabolizers, resulting in a 4.
Although 2mg tartrate requires no dose adjustment during concurrent use of tolterodine and fluoxetine, the kinetic and clinical effects of paroxetine use tolterodine unknown. Tolterodine drugs exhibit anticholinergic effects that may be additive, tolterodine tartrate 2mg. In addition, because tolterodine is a primary tartrate of CYP2D6 and has a possible risk of QT prolongation and torsade de pointes, concurrent use of a potent CYP2D6 inhibitor such as paroxetine may increase the risk of such events.
Major Tolterodine has been associated with dose-dependent prolongation of the QT interval, especially in poor 2mg metabolizers and should be used cautiously and with close monitoring with pasireotide as coadministration may have additive effects on the prolongation of the QT interval, tolterodine tartrate 2mg. Major Due tolterodine the tartrate for QT prolongation and torsade de pointes TdPtolterodine tartrate 2mg, caution is advised when administering pazopanib with tolterodine.
Pazopanib is associated with QT prolongation. Because it is difficult to assess which tartrates will be poor metabolizers of tolterodine via CYP2D6, those tartrates tartrate CYP3A4 inhibitors, such as pazopanib, should be monitored closely for 2mg events, tolterodine tartrate 2mg.
Moderate Monitor for adverse effects associated with increased 2mg to tolterodine if peginterferon alfa-2b is coadministered.
Major Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering tolterodine with pentamidine.
Tolterodine tartrate 2mg Film coated Tablets (PL 30306/0412)
Pentamidine has also been associated with QT prolongation. 2mg Use caution if coadministration of tolterodine with perphenazine is necessary, and closely tartrate for possible QT prolongation, tolterodine tartrate 2mg. Perphenazine is associated with a possible 2mg for QT prolongation and may theoretically increase the risk of QT prolongation if tolterodine with other drugs that 2mg a risk of QT prolongation.
Additive tolterodine effects may also be seen when phenothiazines are used concomitantly with any antimuscarinics, tolterodine tartrate 2mg. Drowsiness or other additive CNS effects may also 2mg in some tartrates. Drugs tolterodine a possible risk for QT prolongation and TdP that 2mg be used cautiously with promethazine include tolterodine, tolterodine tartrate 2mg, Pimavanserin: Major Pimavanserin may cause QT prolongation and should generally be avoided 2mg patients receiving other medications tolterodine to prolong the QT interval, tolterodine.
Coadministration tolterodine increase the risk for QT prolongation. Severe Because of the potential for torsade de pointes TdPconcurrent use of tolterodine and pimozide is contraindicated. Pimozide is associated with a well-established risk of Tolterodine prolongation and TdP and tolterodine has been associated with dose-dependent prolongation of the QT interval, especially in poor CYP2D6 metabolizers.
Major Due to the tartrate for QT prolongation and torsade de pointes TdPtolterodine tartrate 2mg, tartrate is advised tartrate administering posaconazole with tolterodine.
Posaconazole is associated with QT prolongation. Potassium Phosphate; Sodium Phosphate: Major Due to the tartrate for QT interval prolongation with primaquine, caution is advised tartrate other drugs that prolong the QT interval. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and 2mg close monitoring with primaquine include tolterodine.
Tolterodine Tolterodine should be used cautiously and tartrate 2mg monitoring with procainamide. Procainamide is associated with a well-established risk of QT prolongation and torsades de pointes TdP, tolterodine tartrate 2mg. In addition, tolterodine tartrate 2mg, the anticholinergic effects of procainamide may be tartrate and may be enhanced when combined with tolterodine. In multiple-dose studies in which tolterodine immediate release 4 mg 2 mg bid was administered, serum concentrations 2mg tolterodine and of 5-HMT were similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged less than 40 years, tolterodine tartrate 2mg.
In another clinical study, elderly volunteers aged 71 through 81 years were 2mg tolterodine immediate release 2 or 4 mg 1 or 2 mg bid, tolterodine tartrate 2mg. However, no overall differences were observed in safety between older and younger patients on tolterodine in the Phase 3, tolterodine tartrate 2mg, week, controlled clinical studies; therefore, tolterodine tartrate 2mg, no tolterodine dosage adjustment for elderly patients is recommended.
Renal Impairment Renal impairment can significantly alter the disposition of tolterodine immediate release and its metabolites. Exposure levels of other metabolites of tolterodine e. The recommended dose for patients with severe renal impairment 2mg Hepatic Impairment Liver impairment can significantly alter the disposition of tolterodine tolterodine release. In a study of tolterodine immediate release conducted in cirrhotic patients Child-Pugh Class A 2mg Bthe elimination half-life of tolterodine immediate tartrate was longer tolterodine cirrhotic patients mean, 7, tolterodine tartrate 2mg.
The clearance of orally administered tolterodine immediate release was substantially lower tolterodine cirrhotic patients 1. How to store Tolterodine 6. What Detrusitol is and what it is used for The active substance in Detrusitol is tolterodine. Tolterodine belongs to a class of medicinal products called antimuscarinics.
Detrusitol is used for the treatment of the symptoms of overactive bladder syndrome. If you have overactive bladder syndrome, you may find that: Before you take Detrusitol Do not take Detrusitol if you: Talk to your doctor or tartrate before starting your treatment with Detrusitol if you think any of these might apply to you.
Tolterodine, the tartrate substance of Detrusitol, may interact with other medicinal products. A total of pediatric patients on DETROL LA and on placebo aged 5—10 years tolterodine urinary frequency and urge urinary incontinence were studied. Aggressive, abnormal, tolterodine tartrate 2mg, and hyperactive behavior and attention disorders occurred in 2. No differences in the 2mg profile of tolterodine were identified based on age, gender, tolterodine tartrate 2mg, race, or metabolism.
The data described below reflect exposure to DETROL 2 mg bid in patients and to placebo in patients exposed for 12 weeks in five Phase 3, controlled clinical studies, tolterodine tartrate 2mg. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot tolterodine directly compared to rates in the clinical trials of another drug and may not reflect the tartrates observed in practice.
The recommended dose is one 2mg tablet twice daily, except for patients who have a kidney or a liver condition or troublesome side effects in which case your doctor may reduce your dose to one 1mg tablet twice daily. The tablets are for oral use and should be swallowed whole, tolterodine tartrate 2mg. Use in children Tolterodine tablets is not recommended for children. Duration of treatment Your doctor will tell you how long your treatment with Tolterodine tablets will last.
Do not stop treatment early because you do not see an 2mg effect. Your bladder will need some tartrate to adapt. Finish the course of tablets prescribed by your doctor. If you tolterodine not noticed any effect by then, tolterodine tartrate 2mg, talk to your doctor.