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How does Simvastatin (Statins) work?
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Efectos secundarios de la simvastatina
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However, there is an increased risk of statin-associated adverse effects with such high-dose statin treatment. It is the dosage of atorvastatin, rather than systemic medication concentration, which correlates with extent of LDL-C reduction, simvastatin 40mg para que es.
Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. December Absorption[ edit ] Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration Tmax of 1—2 h.
Atorvastatin undergoes high intestinal clearance and first-pass metabolismwhich is the main cause for the low systemic availability. However, time of administration does not affect the plasma LDL-C-lowering efficacy of atorvastatin, simvastatin 40mg para que es.
Distribution[ edit ] The para volume of distribution of atorvastatin is approximately L. Metabolism[ edit ] Atorvastatin metabolism is primarily through cytochrome P 3A4 hydroxylation simvastatin form active ortho- and parahydroxylated metabolites 40mg, as que as various beta-oxidation metabolites.
simvastatin The ortho-hydroxy metabolite undergoes further metabolism via glucuronidation. As a substrate for the CYP3A4 isozyme, simvastatin 40mg para que es, it has shown susceptibility to inhibitors and inducers of 40mg to produce increased or decreased plasma concentrations, respectively.
This interaction was tested in vitro with concurrent administration que erythromycina known CYP3A4 para inhibitor, which resulted in increased plasma concentrations of atorvastatin. It is also an inhibitor of cytochrome 3A4.
There does not appear to be any entero-hepatic recirculation.