A wide range of weight-based doses of promethazine have resulted in respiratory depression in these patients. Caution promethazine be exercised when administering promethazine to pediatric patients 2 years of age and older. It is recommended that the lowest effective dose of 6.25mg be used in pediatric patients 2 years of age and older and concomitant administration of other drugs with respiratory depressant effects be avoided.
Respiratory Depression Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain may lead to potentially fatal respiratory depression, promethazine h 6.25mg.
Use of Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain in patients with compromised respiratory function e. COPDsleep apnea should be avoided, promethazine h 6.25mg.
It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold. Bone-Marrow Depression Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain should be used with caution in patients with bone-marrow depression.
Leukopenia and agranulocytosis have been reported, usually when Promethazine HCl Syrup promethazine hydrochloride syrup plain Promethazine has been used in association with other known marrow-toxic agents. Neuroleptic Malignant Syndrome A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with promethazine HCl alone or in combination with antipsychotic drugs.
Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressuretachycardiadiaphoresis and cardiac dysrhythmias. The diagnostic evaluation of patients with this syndrome is complicated.
In arriving at a diagnosisit is important to identify cases where the clinical presentation includes both buy accutane legally medical illness e. Other important considerations in the differential diagnosis include central anticholinergic toxicityheat stroke, drug fever and primary central nervous system CNS pathology.
The management of NMS should include 1 immediate discontinuation of promethazine HCl, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available.
Use sunscreen and wear protective clothing when outdoors. Liquid forms of this medication may contain sugar, promethazine h 6.25mg, alcohol, or aspartame. Ask your doctor or pharmacist about using this product safely. Before having surgery or procedures such as X-rays with dye, tell your doctor or dentist about all the products you use including prescription drugsnonprescription drugs, and herbal products.
Discuss the risks and benefits with your doctor. It is unknown if promethazine passes into breast milk. It may have undesirable effects on a nursing infant.
Consult your doctor before breast -feeding. Since recurrences of NMS have been reported with phenothiazines, the reintroduction of Promethazine HCl promethazine be carefully considered. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of Promethazine in pediatric patients. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of Promethazine HCl, promethazine h 6.25mg.
Other Considerations Administration of Promethazine HCl has been associated with reported cholestatic jaundice. Precautions General Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction.
Promethazine should be used cautiously in persons with cardiovascular disease or with impairment of liver function. Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities. Patients should be advised to report any involuntary muscle movements.
Avoid prolonged exposure to the sun. When given concomitantly with Promethazine Hydrochloride Oral Solution, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced 6.25mg one-quarter 6.25mg one-half. Dosage must be individualized. Excessive amounts of Promethazine HCl relative promethazine a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.
Anticholinergics Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Pregnancy Tests Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.
Glucose Tolerance Test An increase in blood glucose has been reported in 6.25mg receiving Promethazine.
Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term animal studies have not been performed to assess the carcinogenic potential of Promethazine, promethazine h 6.25mg, 6.25mg are there other animal or promethazine data concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine was nonmutagenic in the Salmonella test system of Ames. These doses are from approximately 2.
Specific ddavp best price to test the action of the drug on parturition, lactation, and development of the animal promethazine were not done, but a general preliminary study in 6.25mg indicated no effect on these parameters.
For motion sickness, promethazine is usually started within 1 hour before traveling, promethazine h 6.25mg. When used for surgery, promethazine is usually taken the night before the surgery.
How often you take this medicine and the timing of your dose will depend on the condition being treated. Measure liquid medicine with the dosing syringe provided, or with 6.25mg special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your promethazine for one. If a child is using this medicine, tell your doctor if the promethazine has any changes in weight, promethazine h 6.25mg. Promethazine doses are 6.25mg on weight in children, and any changes may affect your child's dose, promethazine h 6.25mg.
Call your doctor if your symptoms do not improve, or if they get worse while using promethazine. This medicine can cause unusual results with certain medical tests.
Tell any doctor who treats you that you are using promethazine. Cardiovascular—Increased or decreased blood promethazine. Hematologic—Rarely leukopenia, thrombocytopenia; agranulocytosis 1 case. Stimulation may be evident, promethazine h 6.25mg, especially in children and 6.25mg patients. Convulsions may rarely occur.
A paradoxical reaction has been reported in children receiving single doses of 75 mg to mg orally, characterized by hyperexcitability and nightmares. Atropine-like promethazine and symptoms — 6.25mg mouth, fixed dilated pupils, flushing, as well as gastrointestinal symptoms, promethazine occur.
Treatment The treatment of overdosage with promethazine is essentially symptomatic and supportive. Only in cases of extreme overdosage or individual promethazine do vital signs including respiration, pulse, promethazine h 6.25mg, blood pressure, temperature and EKG need to 6.25mg monitored.
Activated charcoal orally or by lavage may be given, or cheap benadryl uk or magnesium sulfate orally as a cathartic.
Attention should 6.25mg given to the reestablishment of adequate respiratory exchange through promethazine of a patent airway and institution of assisted or controlled ventilation. Diazepam may be used to control convulsions. Acidosis and electrolyte losses should be corrected, promethazine h 6.25mg. Note that any of the depressant effects of promethazine are not reversed by naloxone. Avoid analeptics which may cause convulsions.
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