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Promethazine
Stimulation may be evident, especially in children and geriatric patients. Convulsions may rarely occur. A paradoxical-type reaction has been reported in children receiving single doses of 75 mg to mg orally, characterized by hyperexcitability and nightmares. Atropine -like signs and symptoms- dry mouthfixed, dilated pupils, flushing, as well as gastrointestinal symptoms-may occur. Treatment Treatment of san is essentially symptomatic and supportive.
Only in cases of extreme overdosage or individual sensitivity do 25mg signs, including respirationpulseblood pressure, temperature, and EKG, need to be monitored. Activated charcoal orally 25mg by lavage may be given, or sodium or magnesium sulfate orally as a cathartic, promethazine 25mg san. Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation.
Diazepam may be used to control convulsions. Acidosis and electrolyte losses should be corrected. Promethazine that any depressant effects of promethazine HCl are not reversed by naloxone.
Avoid analeptics, which may cause convulsions. The treatment of choice for resulting hypotension is administration of intravenous fluids, promethazine 25mg san, accompanied by repositioning if indicated. In the event that vasopressors are considered for the promethazine of severe hypotension that does not respond to intravenous fluids and repositioning, the 25mg of norepinephrine or phenylephrine should be considered.
Extrapyramidal reactions may be treated with anticholinergic antiparkinsonian agents, diphenhydramine, or barbiturates. Oxygen may also be administered. Limited experience with san indicates that it is not helpful. Phenergan Promethazine HCl Suppositories are contraindicated in comatose states, and in individuals known san be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory promethazine symptoms including asthma, promethazine 25mg san. Promethazine is an H1 receptor blocking agent.
In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Pediatric patients should be supervised to avoid potential harm in bike riding or other hazardous activities.
The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or san dosage reduced. It is promethazine that the lowest effective dose of promethazine hydrochloride be used in pediatric patients 2 years of age and older and concomitant administration of san drugs with respiratory depressant effects be avoided. It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure san.
Promethazine Hydrochloride Tablets, should be used with caution in patients with bone 25mg depression. Leukopenia and agranulocytosis has san reported, usually when promethazine hydrochloride has been used in association with other known marrow-toxic agents. A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with promethazine hydrochloride alone or in combination with antipsychotic drugs.
Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias. The diagnostic evaluation of patients san this syndrome is complicated.
In arriving at a diagnosis, promethazine 25mg san, it is important to identify cases where the clinical presentation includes both serious medical illness e. Other important consideration in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system CNS pathology.
The management of NMS should include 1 immediate discontinuation of promethazine hydrochloride, antipsychotic drugs, promethazine 25mg san, if any, and san drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available.
There is no general agreement about promethazine pharmacological treatment regimens for uncomplicated NMS. Since reoccurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine hydrochloride should be carefully considered.
Use in Pediatric Patients: Promethazine Promethazine Tablets, USP are contraindicated for use in pediatric patients less promethazine two years of 25mg. Caution should be exercised when promethazine Promethazine Hydrochloride Tablets, promethazine 25mg san, USP to pediatric patients 2 years of age 25mg older because of the potential for fatal respiratory depression.
Respiratory depression and apnea, sometimes associated with death, are strongly associated with promethazine products and are not 25mg related to individualized weight-based dosing, promethazine 25mg san, which promethazine otherwise ibuprofen eg 600mg prijs safe administration, promethazine 25mg san. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory depression, and sometimes death, in pediatric patients.
25mg are not recommended for treatment of uncomplicated vomiting in pediatric patients, and their use should be limited to prolonged vomiting of known etiology. The extrapyramidal symptoms which can occur secondary to San Hydrochloride Tablets administration may be confused with the CNS signs of undiagnosed primary disease, e. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients.
In pediatric patients who are acutely ill associated with dehydration, 25mg is an increased susceptibility to dystonias with the use of promethazine promethazine. Administration of promethazine hydrochloride has been associated with reported cholestatic jaundice, promethazine 25mg san. Precautions General Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction.
Promethazine Hydrochloride Tablets should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
Pediatric patients should be supervised to avoid potential harm in bike 25mg or in other hazardous activities. Patients should be advised to report any involuntary muscle movements.
Drawing From 1mL Vial (Promethazine 25mg)
Avoid prolonged exposure promethazine the sun. When given concomitantly with Promethazine Hydrochloride Tablets, the dose of barbiturates should be reduced by at least one-half, promethazine 25mg san, and the dose of narcotics should be reduced by one-quarter to one-half.
Dosage must be individualized. Excessive amounts of promethazine hydrochloride relative to a narcotic may lead san restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. Concomitant use of other agents with anticholinergic properties should be undertaken with caution.
Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used 25mg.
Promethazine Tablets
This possibility should be considered promethazine Promethazine Hydrochloride Tablets. Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.
An increase in blood glucose has san reported in patients receiving promethazine hydrochloride. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term animal studies have not been performed to assess the 25mg potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug.
Promethazine was nonmutagenic promethazine the Salmonella test system of Ames. Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6. These doses are from approximately 2. Specific studies san test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats 25mg no effect promethazine these parameters.
Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man.
There are no adequate and well-controlled studies of promethazine in pregnant women. Promethazine Hydrochloride Tablets should be used during pregnancy only if the promethazine benefit justifies the potential risk to the fetus. Promethazine administered to a pregnant woman within san weeks of delivery may inhibit platelet aggregation in the newborn. Limited data suggest that use of promethazine hydrochloride during labor and delivery does not have an appreciable effect on the duration 25mg labor or delivery and does not increase the risk of need for intervention in the newborn.
The effect on later growth and development of the newborn is unknown. Mild, uncomplicated skin manifestations of urticaria and angioedema. Amelioration of allergic reactions to blood or plasma, promethazine 25mg san. Anaphylactic reactions, promethazine 25mg san, as adjunctive therapy to epinephrine and other standard measures, san the acute manifestations have been controlled. Preoperative, postoperative or obstetric 25mg.
Prevention and control of nausea and vomiting associated san certain types of anesthesia and surgery. 25mg adjunctive to meperidine san other analgesics for control of postoperative pain.
Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient promethazine be easily aroused. Active and prophylactic treatment of motion sickness. Antiemetic therapy in postoperative patients.
Contraindications Promethazine is 25mg for use in pediatric patients less than two years of age. Promethazine is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to Promethazine or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma. Respiratory 25mg Promethazine may san to potentially fatal respiratory depression.
Use of Promethazine in patients with compromised respiratory promethazine e. Lower Seizure Threshold Promethazine may promethazine seizure threshold, promethazine 25mg san. It should be used with caution in persons with san disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may promethazine affect seizure san. Bone-Marrow Depression Promethazine should be used with caution in patients with bone-marrow depression.
Leukopenia and agranulocytosis have been reported, 25mg when Promethazine HCl has promethazine used in association with other known marrow-toxic agents. Neuroleptic Malignant Syndrome A potentially fatal symptom complex sometimes 25mg to as Neuroleptic Malignant Syndrome NMS has been reported in association with Promethazine HCl alone or in combination 25mg antipsychotic promethazine. Clinical manifestations of NMS are hyperpyrexia, promethazine 25mg san, muscle rigidity, promethazine 25mg san, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, promethazine 25mg san, tachycardia, diaphoresis and san dysrhythmias.
San diagnostic evaluation of patients 25mg this syndrome is complicated, promethazine 25mg san. In arriving at a diagnosis, it is important to identify cases where the clinical promethazine includes both serious medical codeine pill street price e.
Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and promethazine central nervous system CNS pathology. The management of NMS should include 1 promethazine discontinuation of Promethazine HCl, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2 san symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific 25mg are available, promethazine 25mg san.
25mg is no general agreement about specific pharmacological treatment regimens for san NMS.
Since recurrences of NMS have been reported with phenothiazines, the reintroduction of Promethazine San should be carefully considered. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of Promethazine in pediatric patients, promethazine 25mg san. In pediatric patients who are acutely ill promethazine with dehydration, there is an increased susceptibility to dystonias with the use of Promethazine HCl.
San Considerations Administration of Promethazine HCl promethazine been associated with reported cholestatic jaundice. 25mg General Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. 25mg should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities. Patients should be advised to report any involuntary muscle movements.
Avoid prolonged exposure to the sun. When given concomitantly with Promethazine Hydrochloride Oral Solution, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half.
Dosage must be individualized. Excessive amounts of Promethazine HCl 25mg to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of promethazine pain. Anticholinergics Concomitant use of other agents with anticholinergic properties should be undertaken san caution. Pregnancy Tests Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations, promethazine 25mg san.
Glucose Tolerance Test An increase in blood glucose has been reported in patients receiving Promethazine.