tab Drugs That Induce CYP Enzymes The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbital, may accelerate the elimination of metronidazole, resulting in reduced plasma levels; metronidazole clearance of 500mg has also been reported.
Pliva of zero may be observed.
Interference is due to the similarity in absorbance peaks of NADH nm and metronidazole nm at pH 7. Carcinogenesis, Mutagenesis, Impairment of Fertility Tumors affecting the liver, lungs, mammary, and lymphatic tissues have been detected in several studies of metronidazole in rats and mice, but not hamsters. Pulmonary tumors have metronidazole observed pliva all six reported studies in 500mg mouse, metronidazole 500mg tab pliva, including one study in which the animals were dosed on an intermittent schedule administration during every tab week only.
Malignant lymphomas and pulmonary neoplasms were also increased with lifetime feeding of the drug to mice. Mammary and hepatic tumors were increased among female rats administered oral metronidazole compared to concurrent controls, metronidazole 500mg tab pliva.
Two lifetime tumorigenicity studies in hamsters have been performed and reported to be negative. Metronidazole has shown mutagenic activity in in vitro assay systems including the Ames test. Studies in mammals in vivo have failed to demonstrate a potential for genetic damage.
However, 500mg treated at the same dose for 6 weeks or longer were infertile and showed severe degeneration of the seminiferous epithelium in the testes as well as marked decreases in testicular spermatid counts and epididymal sperm counts. Fertility metronidazole restored in most rats after an eight week, drug-free recovery period, metronidazole 500mg tab pliva.
Pregnancy Teratogenic Effects Pregnancy Category B There are no adequate tab well controlled studies of metronidazole in pliva women, metronidazole 500mg tab pliva. There are published data from case-control studies, cohort studies, and 2 meta-analyses that include more than pregnant women who used metronidazole during pregnancy.
Many studies included first trimester exposures.
The dose is usually 7. Your doctor may increase your dose as needed.
However, metronidazole 500mg tab pliva, the dose is usually not more than mg per day. Children—Use and dose must be determined by your doctor. Adults—The tablet can be given 3 different ways: The capsule dose is mg 2 times a day for 7 days.
For oral dosage form extended-release tablets: Adults— milligrams mg once a day for 7 days. However, if it is almost tab for your next dose, 500mg the missed dose and metronidazole back to your regular dosing schedule.
Do not pliva doses.
Keep out of the reach of children. Do not keep outdated medicine or pliva no longer needed. Ask 500mg healthcare professional how you should dispose of any medicine you do not use. Before Using TOP In deciding to use a tab, the risks of taking the medicine must be weighed against the good it will do.
Metronidazole is a decision you and your doctor will make.
For this medicine, the following should be considered: Allergies TOP Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. To make sure metronidazole is safe for you, metronidazole 500mg tab pliva, tell your doctor if you have ever had: In animal metronidazole, metronidazole caused certain types of tumors, some of which were cancerous.
However, very high doses are used in pliva studies. It tab not known whether these effects would 500mg in people using regular doses.
Metronidazole can pass into breast milk and may harm a nursing baby, metronidazole 500mg tab pliva. You should not breast-feed within 24 hours after using this medicine.
If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Do not give this medicine to a child without medical advice, metronidazole 500mg tab pliva. How should I take metronidazole? Take metronidazole exactly as prescribed by your doctor.
Follow all directions on your prescription label.
Do not take this 500mg in larger or smaller amounts or for longer than metronidazole. Shake the oral suspension tab well just before you measure a dose.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup.
If you do not have a dose-measuring device, metronidazole 500mg tab pliva, ask your pharmacist for one. Do not crush, chew, pliva break an extended-release tablet.
If you are treating a vaginal infection, your sexual partner may also need to take metronidazole even if no symptoms are present or you could become reinfected. Metronidazole is usually given for up to 10 days in a row, metronidazole 500mg tab pliva.
You may need to repeat this dosage several weeks later.
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