COX-2 selective inhibitors are not a substitute for venezuela acid for prophylaxis of cardiovascular thrombo-embolic diseases because of their lack of antiplatelet effect. Therefore antiplatelet therapies should not arcoxia discontinued see sections above, 4, arcoxia precio venezuela.
Renal effects Renal prostaglandins may play a compensatory role precio the maintenance of renal perfusion.
Therefore, under conditions of compromised renal perfusion, precio of etoricoxib may cause a reduction in prostaglandin formation and, secondarily, in renal blood flow, venezuela thereby impair renal function. Patients at greatest risk of this response are those with pre-existing significantly impaired renal function, uncompensated heart failure, or cirrhosis.
Monitoring arcoxia renal function in such patients should be considered. Fluid retention, arcoxia precio venezuela, oedema and hypertension As with other medicinal products known to inhibit prostaglandin synthesis, fluid retention, oedema and hypertension have been observed in patients taking etoricoxib.
For information regarding a dose related response for etoricoxib see section 5. Caution should be exercised in patients with a history of cardiac failure, left ventricular dysfunction, or hypertension and in patients with pre-existing oedema from any other reason.
If there is clinical evidence precio deterioration in the condition of these patients, appropriate measures including discontinuation of arcoxia should be taken. Etoricoxib may be associated venezuela more frequent and severe hypertension than some other NSAIDs and selective COX-2 inhibitors, particularly at high doses. Therefore, hypertension should be controlled before treatment with etoricoxib see section 4, arcoxia precio venezuela.
Blood pressure should be monitored within two weeks precio initiation of treatment and periodically thereafter. If blood pressure rises significantly, alternative treatment should be considered. Precio signs arcoxia hepatic insufficiency occur, or if persistently abnormal liver function tests venezuela times the upper limit of arcoxia are detected, etoricoxib should be discontinued.
Venezuela If during treatment, patients deteriorate in any of the organ system functions described above, arcoxia precio venezuela, appropriate measures should be taken and discontinuation of etoricoxib therapy should be considered.
Medically appropriate supervision should be maintained when using etoricoxib in the elderly and in patients with renal, hepatic, or cardiac dysfunction.
Caution should be used when initiating treatment with etoricoxib precio patients with dehydration. It is advisable to rehydrate patients prior to starting therapy with etoricoxib. Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs and some selective COX-2 inhibitors during post-marketing surveillance see section 4.
Patients appear to be at highest risk for these reactions early in the course of therapy with the onset of the reaction venezuela in the majority of cases within the first month of treatment. Serious hypersensitivity reactions such as anaphylaxis and angioedema have been reported in patients receiving etoricoxib see section 4.
Some selective COX-2 inhibitors have been associated with an increased risk of skin reactions in patients with a history of any drug allergy, arcoxia precio venezuela. Etoricoxib should be discontinued at the first appearance of skin precio, mucosal lesions, arcoxia precio venezuela, or any other sign of hypersensitivity.
Etoricoxib may mask fever and other signs of inflammation. Caution should be exercised arcoxia co-administering etoricoxib with warfarin or other oral anticoagulants see section 4. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine, arcoxia precio venezuela.
Therefore, patients receiving oral anticoagulants should be closely monitored for their prothrombin time INR, particularly in the first few days when therapy with etoricoxib arcoxia initiated or venezuela dose of etoricoxib is changed see section 4.
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