Before taking this medicine You should not use Zofran if: To make sure Zofran is safe for you, tell your doctor if you have: Zofran is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old.

How should I take Zofran? Take Zofran exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Zofran can be taken with or without food.

The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully. Take the regular tablet with a full glass of water. Dihydroergotamine Mesylate — Marketed under the brand name Migranal. Diphenhydramine — Marketed under the brand names Dramamine and Benadryl. Disopyramide Phosphate — Marketed under the brand name Norpace. Divalproex Sodium — Marketed under the brand name Depakote.

Donepezil Hydrochloride — Marketed under the brand name Aricept. Dorzolamide Hydrochloride — Marketed under the brand names Cosopt and Trusopt.

Doxepin Hydrochloride — Marketed under the brand name Prudoxin. Doxercalciferol — Marketed under the brand name Hectorol.

Doxorubicin Hydrochloride Liposome — Marketed under the brand name Doxil. Duloxetine Hydrochloride — Marketed under the brand name Cymbalta. Eletriptan Hydrobromide — Marketed under the brand name Relpax.

Enalapril Maleate with Hydrochlorothiazide — Marketed under the brand name Vaseretic. Enalapril Maleate — Marketed under the brand name Vasotec. Enalaprilat Enfuvirtide — Marketed under the brand name Fuzeon. Enoxacin — Marketed under the brand name Penetrex.

Entacapone — Marketed under the brand name Comtan. Eprosartan Mesylate — Marketed under the brand name Teveten. Escitalopram Oxalate — Marketed under the brand name Lexapro. Esmolol Hydrochloride — Marketed under the brand name Brevibloc. Esomeprazole Magnesium — Marketed under the brand name Nexium. Estazolam — Marketed under the brand name Prosom. Eszopiclone — Marketed under the brand name Lunesta. Etanercept — Marketed under the brand name Enbrel. Famotidine — Marketed under the brand name Pepcid.

Felodipine — Marketed under the brand name Plendil. Fenofibrate — Marketed under the brand names Antara, Lofibra, and Tricor. Fenoprofen Calcium — Marketed under the brand name Nalfon. Fentanyl — Marketed under the brand name Duragesic. Fentanyl Citrate — Marketed under the brand name Actiq. Fexofenadine Hydrochloride — Marketed under the brand name Allegra-D. Flecainide Acetate — Marketed under the brand name Tambocor.

Fluoxetine Hydrochloride — Marketed under the brand name Prozac. Fluoxetine Hydrochloride with Olanzapine — Marketed under the brand name Symbyax. Flurazepam Hydrochloride — Marketed under the brand name Dalmane. Fluvoxamine Maleate — Marketed under the brand name Luvox.

Formoterol Fumarate — Marketed under the brand name Foradil. Foscarnet Sodium — Marketed under the brand name Foscavir. Fosinopril Sodium — Marketed under the brand name Monopril.

Frovatriptan Succinate — Marketed under the brand name Frova. Furosemide — Marketed under the brand name Lasix. Gabapentin — Marketed under the brand name Neurontin. Galantamine Hydrobromide — Marketed under the brand name Razadyne. Ganciclovir — Marketed under the brand name Cytovene. Gemifloxacin Mesylate — Marketed under the brand name Factive. Glatiramer Acetate — Marketed under the brand name Copaxone.

Glycopyrrolate — Marketed under the brand name Robinul. Goserelin Acetate — Marketed under the brand name Zoladex. Grepafloxacin Hydrochloride — Marketed under the brand name Raxar. Guanadrel Sulfate — Marketed under the brand name Hylorel. Guanfacine Hydrochloride — Marketed under the brand name Tenex.

Guanidine Hydrochloride — Marketed under the brand name Guanidine. Haloperidol — Marketed under the brand name Haldol. Hydrochlorothiazide Hydrochlorothiazide with Triamterene — Marketed under the brand name Dyazide. Hydrocodone Bitartrate with Ibuprofen — Marketed under the brand name Vicoprofen. Hyoscyamine — Marketed under the brand names Cystospaz, Levbid, and Nulev.

Ibuprofen — Marketed under the brand names Advil and Motrin. Ibuprofen with Oxycodone Hydrochloride — Marketed under the brand name Combunox. Imipramine Pamoate — Marketed under the brand name Tofranil. Interferon Alfa-2b, Recombinant — Marketed under the brand name Intron. Interferon Alfacon-1 — Marketed under the brand name Infergen.

Interferon Beta-1a — Marketed under the brand name Rebif. Ipratropium Bromide — Marketed under the brand name Atrovent. Isosorbide Mononitrate — Marketed under the brand names Imdur and Monoket. Isotretinoin — Marketed under the brand names Accutane and Amnesteem.

Isradipine — Marketed under the brand name Dynacirc. Ketoprofen — Marketed under the brand name Orudis. Ketotifen Fumarate — Marketed under the brand name Zaditor. Lamotrigine — Marketed under the brand name Lamictal. Lansoprazole — Marketed under the brand name Prevacid. Leflunomide — Marketed under the brand name Arava. Leuprolide Acetate — Marketed under the brand names Lupron and Viadur. Levalbuterol Hydrochloride — Marketed under the brand name Xopenex.

Levofloxacin — Marketed under the brand name Levaquin. Levomethadyl Acetate Hydrochloride — Marketed under the brand name Orlaam. Levorphanol Tartrate — Marketed under the brand name Levorphanol. Lisinopril — Marketed under the brand names Prinivil and Zestril. Lisinopril with Hydrochlorothiazide — Marketed under the brand name Zestoretic. Do not take extra medicine to make up the missed dose. Seek emergency medical attention or call the Poison Help line at Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Tell your doctor about all other medicines you use, especially: To prevent nausea from radiation treatment, take this medication by mouth 1 to 2 hours before the start of your treatment. To prevent nausea after surgery, take ondansetron by mouth 1 hour before the start of surgery.

This medication may be taken with or without food. However, your doctor may tell you not to eat before chemotherapy, radiation, or surgery. If you are using the liquid form of this medication, use a special measuring spoon or device to measure out your prescribed dose. Do not use a household spoon because you may not get the correct dose. Take any other doses as directed by your doctor. Ondansetron may be taken up to 3 times a day for 1 to 2 days after your chemotherapy or radiation treatment is finished.

Zofran (ondansetron) Drug Interactions

Cyclosporine — Marketed under the brand names Gengraf and Neoral. Skip the missed dose if it is almost time for your next scheduled medication. In clinical trials, Zofran prolongation has been reported in patients who received midostaurin as single-agent therapy or in combination with cytarabine and daunorubicin. Fexofenadine Hydrochloride — Marketed under the brand name Allegra-D. If coadministration is necessary, monitor ECG. Moderate Plasma concentrations of ondansetron, a P-glycoprotein P-gp with, may be increased zofran administered concurrently with voxilaprevir, zofran with other medications, a P-gp inhibitor. Minor If ondansetron and fluphenazine with be coadministered, ECG medication is recommended. Methyldopate Hydrochloride — Marketed other the brand name Aldomet. Furosemide — Marketed under the brand name Lasix. Rivastigmine Tartrate — Marketed under the brand name Exelon.

Vomiting and Antiemetic Drugs

Zofran for Migraine (fight nausea)

Ondansetron is a substrate of the drug efflux transporter P-glycoprotein PGP and of the hepatic isoenzyme CYP3A4; boceprevir is an inhibitor of both the efflux protein and the isoenzyme. Grepafloxacin Hydrochloride — Marketed under the brand name Raxar. Goserelin Acetate — Marketed under the brand name Zoladex. Ondansetron is a substrate of the drug transporter P-glycoprotein P-gp ; ledipasvir is a P-gp inhibitor, zofran with other medications. Esomeprazole Magnesium — Marketed under the brand name Nexium. The mean increase in QTc is about 6 milliseconds, measured at the tmax of the maximum dosage mg PO twice daily. Fluphenazine is associated with a possible risk for QT prolongation. Ondansetron may be taken up to 3 times a day for 1 to 2 days after your chemotherapy or radiation treatment is finished. Ondansetron has been associated with QT prolongation and postmarketing reports of TdP. Emtricitabine; Rilpivirine; Tenofovir alafenamide: Major Coadministration of ondansetron and citalopram is not recommended due to the potential for QT prolongation.

ondansetron - oral, Zofran

Belladonna Alkaloids with Phenobarbital — Marketed under the brand name Donnatal. Major Due to an increased with for Other prolongation and torsade de pointes TdPcaution is other when administering ondansetron with ofloxacin. Be careful if you drive or do anything that requires you to be alert, zofran with other medications. Ask your medication or with if you have questions. A study of overpregnancies in Denmark found that ondansetron during pregnancy was not associated with a significantly increased risk of spontaneous abortionstillbirthmajor birth defectpreterm birthlow birth weightor small for gestational age. Hyoscyamine — Marketed under the brand names Cystospaz, Levbid, and Nulev. Major Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering ondansetron with flecainide. Allow it to dissolve in your mouth without chewing. Topiramate zofran Marketed under the brand name Topamax, zofran with other medications. Ondansetron has been associated with a dose-related increase in the QT interval and post-marketing reports of TdP. However, your doctor may tell you not to eat before chemotherapy, radiation, or surgery. TdP and sudden death have been reported in patients receiving vandetanib; ondansetron also has a possible risk zofran QT prolongation. Major Serotonin syndrome can occur during concomitant use of opiate agonists with serotonergic drugs, such as serotonin-receptor antagonists. Patients who have taken antidepressants for their IBS symptoms have reported significant improvement in their abdominal pain and reduction in other IBS symptoms, such as diarrhea, zofran with other medications, constipation, bloating, medication or urgency. Minor Ondansetron may cause a decrease in the serum concentration of cyclophosphamide if the two drugs are coadministered.

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