Quick GuidePrescription Drug Abuse: Taking steroid drugs affects the functioning and hormone secretion pattern of the adrenal glands, since these glands are the source of many natural steroid hormones. For this reason, when doctors prescribe steroids, their discontinuation is always tapered gradually taking smaller doses to allow the adrenal glands to return to their normal pattern of function and secretion.
Likewise, abrupt discontinuation of anabolic steroid use can also result in withdrawal symptoms that can be dangerous and even potentially fatal. The drug simulated cortisol, a naturally occurring, anti-inflammatory hormone produced by the adrenal glands. Such synthetic corticosteroid drugs prednisone, prednisolone, and many others have since benefited patients and are commonly used to treat many conditions, including allergic reactions, asthma , rheumatoid arthritis , and inflammatory bowel disease.
They are not without serious drawbacks, however. The two major problems related to continuous, long-term steroid treatment are drug side effects and symptoms due to changes in the balance of normal hormone secretion. The latter typically results from taking doses greater than our body's natural production about the equivalent of 7. Many people report severe body aches when they stop taking this drug. These aches may last for weeks following your last dose of the drug.
If they become too intense, you should consider tapering more gradually. Since Prednisone is associated with significant increases in appetite, when you stop taking it, you will likely notice a major decrease in appetite. You may have constantly felt hungry while on it, but when you quit taking it, your appetite will significantly drop off.
Another common symptom to experience upon discontinuation is that of depression. You may feel very depressed in conjunction with significantly low levels of energy. This is in part due to lack of stimulation. Your adrenal stores need to build themselves back up for you to feel normal. Just know that your brain and body will eventually fully heal as time passes.
Some people report diarrhea when they first come off of this drug. If you are experiencing this, be sure to pick up some Imodium available over the counter — it should help ease this particular symptom.
This is a common withdrawal symptom from any drug. If you feel dizzy, just know that it should go away within a few weeks. The most intense dizziness should subside after the drug has been out of your system for a week. Most people end up having to deal with extreme levels of fatigue and low energy when they quit this drug. If you feel fatigued, just know that it is a result of your body withdrawing from a drug that it has depended on for functioning for a long period of time.
Additionally you no longer have adequate amounts of cortisol to provide the body with energy. It will take some time before these homeostatic levels are reestablished. Some individuals report having a fever when they stop this drug. The fever should not last more than a week or so after your last dose. Since this drug actually helps many people with severe headaches, coming off of it may result in even more extreme headaches than initially experienced. Some individuals report constant headaches, while others report full-blown migraines during withdrawal.
Anyone who has taken this drug for an extended period of time will exhibit changes in their HPA hypothalamus-pituitary-adrenal axis. In other words, the adrenals are no longer producing sufficient levels of cortisol because they have become accustomed to receiving the Prednisone.
Impaired quality of life by vague involvement of multiple systems like joint pain also known as arthralgia , muscle aches, mental changes, or changes in the serum concentration of calcium. In some susceptible patients, abrupt prednisone withdrawal may also lead to severe complications like acute adrenal crisis, which is a life-threatening condition that is marked by high grade fever, excessive sweating, changes in the complexion of skin, low blood pressure, dehydration, abdominal pain, flank pain, joint pain, changes in heart rate, rigors and shaking chills - ultimately culminating in confusion, delirium and coma or even death.
What is the Pathophysiology of Prednisone Withdrawal Symptoms? The human body is very sensitive and calculated when it comes to the maintenance of its internal environment, so in situations where we consume glucocorticoids from external sources like prednisone , the human adrenal glands shut down the production of glucocorticoids.
This creates a deficit in internal production, but as long as you are getting prednisone from external sources, no complications or adverse effects are observed. However, in case of abrupt cessation [2] , the human body retaliates to low glucocorticoids by: Increasing the susceptibility of developing infections.
Creating immune dysfunctions in the body. There can be irregularity of periods caused by hormonal imbalance as a result of drug withdrawal. Body Ache and Fever: Fever and body ache can also be observed due to the weak immune system. Hormonal imbalance may result in depression.
Nausea is considered as a serious withdrawal symptom. Prednisone withdrawal can also lead fainting. If two or three of the above symptoms occur at a time, it is known as prednisone withdrawal syndrome.
So it is necessary to taper prednisone and not stop it abruptly. Reduce the dosage of prednisone slowly, and gradually discontinue it.
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