Respiratory depression, nightmares, delirium , and agitated behavior have also been reported in some of these patients. When given concomitantly with Phenergan Promethazine HCl Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.

Epinephrine — Because of the potential for promethazine HCl to reverse epinephrine 's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Promethazine HCl Suppositories overdose.

Anticholinergics — Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Pregnancy Tests Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. Glucose Tolerance Test An increase in blood glucose has been reported in patients receiving promethazine HCl.

It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold. Leukopenia and agranulocytosis have been reported, usually when promethazine HCl has been used in association with other known marrow-toxic agents. Neuroleptic Malignant Syndrome A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with promethazine HCl alone or in combination with antipsychotic drugs.

Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia , diaphoresis and cardiac dysrhythmias. The diagnostic evaluation of patients with this syndrome is complicated.

In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illnesses e. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke , drug fever and primary central nervous system CNS pathology.

The management of NMS should include 1 immediate discontinuation of promethazine HCl, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.

Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl should be carefully considered. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine HCl in pediatric patients. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl.

Other Considerations Administration of promethazine HCl has been associated with reported cholestatic jaundice. Phenergan Promethazine HCl Suppositories should be used cautiously in persons with cardiovascular disease or with impairment of liver function. Carcinogenesis, Mutagenesis, Impairment Of Fertility Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug.

Promethazine was nonmutagenic in the Salmonella test system of Ames. This drug can often cause excitement in young children instead of drowsiness. Special care should be taken when using this medication in children who have lost a lot of fluid dehydration , those who have a family history of sudden infant death syndrome SIDS , and those who are hard to wake up from sleep.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation , or trouble urinating. Drowsiness and confusion can increase the risk of falling.

During pregnancy , this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if promethazine passes into breast milk.

It may have undesirable effects on a nursing infant. Consult your doctor before breast -feeding. Maximum daily dose 25 mg. Increasing to a maximum of 25 mg bd as required. The use of Phenergan Elixir is recommended for this age group.

Children over 10 years and adults including elderly 25 mg to be taken the night before the journey. To be repeated after 6—8 hours as required. As a paediatric sedative for short term use and for short term treatment of insomnia in adults: Children years 25 mg as a single night time dose. Children over 10 years and adults including elderly 25 or 50 mg as a single night time dose. Phenergan should not be given to patients with a known hypersensitivity to promethazine or to any of the excipients.

Promethazine is contraindicated for use in children less than two years of age because of the potential for fatal respiratory depression.. Phenergan should be avoided in patients taking monoamine oxidase inhibitors up to 14 days previously. It should therefore be used with caution in patients with asthma, bronchitis or bronchiectasis. Use with care in patients with severe coronary artery disease, narrow angle glaucoma, epilepsy or hepatic and renal insufficiency.

Caution should be exercised in patients with bladder neck or pyloro-duodenal obstruction. The use of promethazine should be avoided in children and adolescents with signs and symptoms suggestive of Reye's Syndrome. Promethazine may mask the warning signs of ototoxicity caused by ototoxic drugs e.

It may also delay the early diagnosis of intestinal obstruction or raised intracranial pressure through the suppression of vomiting. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Phenergan should not be used for longer than 7 days without seeking medical advice.

¿Qué es PROMETHAZINE INJ. I.M. 50 MG/ML y para qué sirve?

Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardiadiaphoresis and cardiac dysrhythmias. When the weather is hot, drink a lot of fluids and dress lightly. Photosensitive skin secundarios have been reported. As efectos paediatric sedative for short term use and for short term treatment of insomnia in adults: It should therefore be used with caution in patients with asthma, bronchitis or bronchiectasis. Convulsions may occur in both adults and children: Anticholinergic side effects such as blurred vision, dry mouth and urinary retention occur occasionally. Respiratory — Asthmanasal stuffiness, respiratory depression potentially fatal and apnea potentially fatal. Note that any depressant effects of promethazine HCl are not reversed by naloxone. If the patient is seen soon enough after ingestion, it should be possible to induce vomiting with ipecacuanha despite the antiemetic effect phenergan promethazine; alternatively, gastric lavage may be used, phenergan 50 mg efectos secundarios. This drug may make you dizzy or drowsy or blur your vision. Children years 25 mg as a single night time dose. It may also delay the early diagnosis of intestinal obstruction or raised intracranial pressure through the suppression of vomiting.

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