Do not crush or chew the granules. Sprinkle the granules on 1 teaspoon 5 milliliters of applesauce and swallow all of the mixture right away within 10 minutes. Follow with sips of water. Or you can mix the granules with 1 teaspoon 5 milliliters of apple juice in a small cup, stir for 5 seconds, and swallow all of the mixture right away.
To make sure you take the entire dose, rinse the cup once or twice with apple juice to mix any remaining granules, and swallow the juice. Some patients have received treatment with pantoprazole for more than 2 years. Usual Adult Dose for Peptic Ulcer: Dosage Information in more detail What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at What should I avoid while using pantoprazole? This medicine can cause diarrhea, which may be a sign of a new infection.
If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to. Pantoprazole side effects Get emergency medical help if you have signs of an allergic reaction to pantoprazole: Call your doctor at once if you have: Increased exposure of other antiretroviral drugs e. There are other antiretroviral drugs which do not result in clinically relevant interactions with pantoprazole sodium.
See prescribing information for atazanavir for dosing information. See prescribing information for nelfinavir. See the prescribing information for saquinavir for monitoring of potential saquinavir-related toxicities.
See prescribing information for specific antiretroviral drugs. Increased INR and prothrombin time in patients receiving PPIs, including pantoprazole sodium, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death.
Drugs Dependent on Gastric pH for Absorption e. Pantoprazole sodium can reduce the absorption of other drugs due to its effect on reducing intragastric acidity Intervention: Co-administration of pantoprazole sodium in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid MPA , possibly due to a decrease in MMF solubility at an increased gastric pH.
See the prescribing information for other drugs dependent on gastric pH for absorption. An alternative confirmatory method should be considered to verify positive results. Consider additional follow-up and diagnostic testing in adult patients who have a suboptimal response or an early symptomatic relapse after completing treatment with a PPI.
There are no hidden charges or membership fees, and every purchase is fully refundable. You have literally saved my life! Prepay online to lock in your savings. Bring your prescription to a participating pharmacy and have them fill it, as usual.
At pickup, show the pharmacist your Blink Card, and have them process it as the primary payor. No formal drug interaction studies of high-dose methotrexate with PPIs have been conducted [see Warnings and Precautions 5.
A temporary withdrawal of Pantoprazole sodium may be considered in some patients receiving high-dose methotrexate. Drugs Dependent on Gastric pH for Absorption e. Pantoprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.
The clinical relevance of reduced MPA exposure on organ rejection has not been established in transplant patients receiving Pantoprazole sodium for Injection and MMF. Use Pantoprazole sodium with caution in transplant patients receiving MMF. See the prescribing information for other drugs dependent on gastric pH for absorption. CgA levels increase secondary to PPI-induced decreases in gastric acidity. The increased CgA level may cause false positive results in diagnostic investigations for neuroendocrine tumors [see Warnings and Precautions 5.
Temporarily stop Pantoprazole sodium treatment at least 14 days before assessing CgA levels and consider repeating the test if initial CgA levels are high. If serial tests are performed e. There have been reports of false positive urine screening tests for tetrahydrocannabinol THC in patients receiving PPIs [see Warnings and Precautions 5.
An alternative confirmatory method should be considered to verify positive results. The studies have revealed no evidence of impaired fertility or harm to the fetus due to Pantoprazole. A pre- and postnatal development toxicity study in rats with additional endpoints to evaluate the effect on bone development was performed with Pantoprazole sodium. There were no drug-related findings in maternal animals. The femur findings included lower total area, bone mineral content and density, periosteal and endosteal circumference, and cross-sectional moment of inertia.
Pantoprazole does not accumulate, and its pharmacokinetics are unaltered with multiple daily dosing. Following oral or intravenous administration, the serum concentration of pantoprazole declines biexponentially, with a terminal elimination half-life of approximately one hour.
In extensive metabolizers with normal liver function receiving an oral dose of the enteric-coated 40 mg pantoprazole tablet, the peak concentration Cmax is 2. Following intravenous administration of pantoprazole to extensive metabolizers, its total clearance is 7.
Absorption After administration of a single or multiple oral 40 mg doses of pantoprazole sodium delayed-release tablets, the peak plasma concentration of pantoprazole was achieved in approximately 2.
Pantoprazole absorption is not affected by concomitant administration of antacids. Administration of pantoprazole sodium delayed-release tablets with food may delay its absorption up to 2 hours or longer; however, the Cmax and the extent of pantoprazole absorption AUC are not altered. Thus, pantoprazole sodium delayed-release tablets may be taken without regard to timing of meals. Distribution The apparent volume of distribution of pantoprazole is approximately Metabolism Pantoprazole is extensively metabolized in the liver through the cytochrome P CYP system.
Pantoprazole metabolism is independent of the route of administration intravenous or oral. There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activity. There was no renal excretion of unchanged pantoprazole. No dosage adjustment is recommended based on age. A pediatric granule formulation was studied in children through 5 years of age, and pantoprazole delayed-release tablets were studied in children older than 5 years.
In a population PK analysis, total clearance increased with increasing bodyweight in a non-linear fashion. The total clearance also increased with increasing age only in children under 3 years of age.
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