Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus.
In the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus. Perform serial ultrasound examinations to assess the intra-amniotic environment. If oligohydramnios is observed, discontinue Cozaar, unless it is considered lifesaving for the mother.
Fetal testing may be appropriate, based on the week of pregnancy. Patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury.
Closely observe infants with histories of in utero exposure to Cozaar for hypotension, oliguria, and hyperkalemia [see Use in Specific Populations 8. Losartan potassium has been shown to produce adverse effects in rat fetuses and neonates, including decreased body weight, delayed physical and behavioral development, mortality and renal toxicity.
These findings are attributed to drug exposure in late gestation and during lactation. Significant levels of losartan and its active metabolite were shown to be present in rat fetal plasma during late gestation and in rat milk. Nursing Mothers It is not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk.
Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use Neonates with a history of in utero exposure to Cozaar: If oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion.
Antihypertensive effects of Cozaar have been established in hypertensive pediatric patients aged 6 to 16 years. No overall differences in effectiveness or safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
Race In the LIFE study, Black patients with hypertension and left ventricular hypertrophy treated with atenolol were at lower risk of experiencing the primary composite endpoint compared with Black patients treated with Cozaar both cotreated with hydrochlorothiazide in the majority of patients. We are about to install a water softener in our house and would be using potassium cloride in the processing. Is there a danger of consuming this in my drinking and cooking water? Losartan is approved for the treatment of hypertension high blood pressure , diabetic nephropathy in patients with type 2 diabetes that have a history of hypertension and for stroke risk reduction in patients that have hypertension and left ventricular hypertrophy.
According to medical references, patients should avoid using potassium supplements or salt substitutes unless authorized by a physician. There is a warning about salt substitutes because of the high levels of potassium that are contained in some of them. According to the prescribing information for losartan, potassium ingested with the medication can result in increases in potassium levels in the blood.
There is no mention of potassium from water softeners in the prescribing information. Contact the manufacturer of the water softener and inquire about how much potassium chloride is contained in the water. The company may be able to provide you with additional information regarding risks of drug interactions.
Take losartan exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take losartan with or without food. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. Your blood pressure will need to be checked often.
Diuretics water pills Losartan can cause low blood pressure. Your risk of low blood pressure is increased if you also take diuretics. Symptoms of low blood pressure can include dizziness or feeling faint, or chest pain. Examples of diuretics include: Taking losartan with drugs that contain potassium, or salt substitutes with potassium, can increase your risk of hyperkalemia high levels of potassium.
Examples of these drugs include: However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. This drug comes with several warnings. Allergy warning Losartan can cause a severe allergic reaction. Taking it again could be fatal cause death. Alcohol interaction warning Using drinks that contain alcohol while taking losartan can cause a sedative effect.
This list is not complete. Other drugs may interact with losartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Where can I get more information? Your pharmacist can provide more information about losartan.
NSAIDs may also reduce the blood pressure-lowering effects of losartan. You may need to decide whether to stop breastfeeding or stop taking this medication. Do not take extra medicine to make up the missed dose. Older adults may process drugs more slowly. When pregnancy is detected, discontinue losartan as soon as possible. This can be dangerous if you 100 or use other machinery. Talk to your doctor or pharmacist about the medications you take. While maximum plasma concentrations of losartan and its active metabolite are approximately equal, the AUC area under the curve of the metabolite is about 4 times as great as that of losartan, cozaar 50 mg 100. The dosage information below is for the conditions that losartan is most often prescribed to treat. The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic vagal stimulation. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially cozaar you also have fever, unusual tiredness, and dark colored urine.
A typical adult dosage may 100 levels of this drug to be higher than normal. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. Generally speaking, drug interactions fall into three main categories: The flyer with the drug says not to use salt 100. Studies show a risk of adverse effects to the fetus when the mother takes the drug. Drug information contained herein may be time sensitive, cozaar 50 mg 100. However, because cozaar interact differently in each person, we cannot guarantee that this information includes all possible interactions. Hepatic Impairment The cozaar starting dose of Cozaar is 25 mg in patients with mild-to-moderate hepatic impairment. Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to. These findings are attributed to drug exposure in late gestation and during lactation.
Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Seek emergency medical attention or call the Poison Help line at Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases. According to the prescribing 100 for Cozaar, the brand-name of losartan, cozaar 50 mg 100, cozaar urinary frequency is a possible side effect associated with this cozaar. This medication is used cozaar treat hypertension high blood pressure and works by relaxing blood vessels which helps to lower blood pressure. Drinking alcohol can further lower 100 blood pressure and may increase certain side effects of losartan. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Symptoms of worsening kidney disease include: In long-term follow-up studies without placebo control the effect of losartan appeared to be maintained for up to a year. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment. Nursing Mothers It is not known whether losartan is excreted in human milk, but significant levels of losartan 100 its active metabolite were shown to be present cozaar rat milk, cozaar 50 mg 100. What other drugs will affect losartan Cozaar? Your doctor may occasionally change your dose to make sure you get the best results. Bipolar disorder drug Taking lithium with losartan may increase the levels of lithium in your body. Monitor serum potassium in such patients. Alcohol can cause dehydration and increase the risk for 100 hypotension which is a sudden drop in blood pressure upon lamisil at cream for athlete's foot review from a sitting position.
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