Clindamycin dosage modification may not be necessary in patients with renal disease. In patients with moderate to severe liver disease, prolongation of clindamycin half-life has been found. However, it was postulated from studies that when given every eight hours, accumulation should rarely occur.

Therefore, dosage modification in patients with liver disease may not be necessary. However, periodic liver enzyme determinations should be made when treating patients with severe liver disease. They do not treat viral infections e.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic.

If this occurs, patients should contact their physician as soon as possible. Laboratory Tests During prolonged therapy, periodic liver and kidney function tests and blood counts should be performed.

Drug Interactions Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Clindamycin is metabolized predominantly by CYP3A4, and to a lesser extent by CYP3A5, to the major metabolite clindamycin sulfoxide and minor metabolite N-desmethylclindamycin.

Treat for 7 to 10 days for naturally acquired infection and for up to 60 days for a bioterrorism-related event. For the treatment of systemic anthrax infection. Intravenous dosage Adults mg IV every 8 hours in combination with appropriate antimicrobial therapy.

Clindamycin in combination with a bactericidal antimicrobial i. Clindamycin in combination with a fluoroquinolone and beta-lactam is an alternative therapy for systemic anthrax infection in which meningitis cannot be excluded. For systemic infection without CNS involvement, treatment should continue for at least 14 days or until clinical criteria for improvement are met. For systemic infection in which meningitis cannot be excluded, treatment should continue for at least 2 to 3 weeks or until clinical criteria for improvement are met.

Prophylaxis to complete an antimicrobial course of up to 60 days will be required in both cases. Treat for at least 2 to 3 weeks or until clinical criteria for improvement are met. Prophylaxis to complete an antimicrobial course of up to 60 days is required. Clindamycin in combination with a fluoroquinolone is recommended as the preferred oral follow-up combination therapy for severe anthrax non-CNS infection.

Treatment should continue to complete a treatment course of at least 14 days. Prophylaxis to complete an antimicrobial course of up to 60 days may be required. Clindamycin in combination with a fluoroquinolone is recommended as the preferred oral follow-up combination therapy for severe anthrax. Treatment should continue to complete a treatment course of 10 to 14 days or more. Clindamycin is recommended as an alternative therapy to ciprofloxacin or doxycycline for postexposure prophylaxis.

Treat for 60 days after exposure. Clindamycin is recommended as an alternative therapy to ciprofloxacin or doxycycline term neonates and older for postexposure prophylaxis. Clindamycin is recommended as an alternative therapy to ciprofloxacin for postexposure prophylaxis. Intravenous dosage Adults mg IV every 6 hours plus pyrimethamine and leucovorin is recommended by the HIV guidelines as an alternative therapy in sulfonamide-intolerant patients. Treatment duration should be at least 6 weeks; however, a longer duration may be necessary if clinical or radiologic disease is extensive or if the response is incomplete at 6 weeks.

Chronic maintenance therapy should start after acute treatment. Adjunctive corticosteroids may be administered when clinically indicated for the treatment of mass effect attributed to focal lesions or associated edema; however discontinue as soon as possible.

Anticonvulsants may be administered to patients with a seizure history during the acute treatment phase; however they should not be used prophylactically. Adolescents mg IV every 6 hours plus pyrimethamine and leucovorin is recommended by the HIV guidelines as an alternative therapy in sulfonamide-intolerant patients. Adjunctive corticosteroids may be administered when clinically indicated for the treatment of mass effect attributed to focal lesions or associated edema; however, discontinue as soon as possible.

Anticonvulsants may be administered to patients with a seizure history during the acute treatment phase; however, they should not be used prophylactically. Infants and Children 5 to 7. For acquired toxoplasmosis, treatment duration should be at least 6 weeks; however, a longer duration may be necessary if clinical or radiologic disease is extensive or if the response is incomplete at 6 weeks. For congenital toxoplasmosis, treatment duration is for 12 months. Oral dosage Adults mg PO every 6 hours plus pyrimethamine and leucovorin is recommended by the HIV guidelines as an alternative therapy in sulfonamide-intolerant patients.

Adolescents mg PO every 6 hours plus pyrimethamine and leucovorin is recommended by the HIV guidelines as an alternative therapy in sulfonamide-intolerant patients. Oral dosage Adults mg PO every 8 hours in combination with pyrimethamine plus leucovorin. Unlike the preferred regimen containing sulfadiazine and pyrimethamine, this regimen does not provide adequate prophylaxis against Pneumocystis pneumonia. Adolescents mg PO every 8 hours in combination with pyrimethamine plus leucovorin.

Prophylaxis should not be discontinued in children younger than 1 year of age. Of note, dosing information is extrapolated from adult data and medication regimens for other indications; data using clindamycin and primaquine in children with PCP are not available.

Switch to oral clindamycin as soon as feasible for a total treatment course of 7 days. The CDC recommends clindamycin as an option for chloroquine-resistant infections and for infections of unknown resistance; may also be used for chloroquine-sensitive infections if necessary. Intravenous dosage Adults to mg IV every 6 hours in combination with quinine for 7 to 10 days.

For cases of severe babesiosis, a longer duration of therapy may be necessary. Oral dosage Adults mg PO every 8 hours in combination with quinine for 7 to 10 days. For cases of severe babesiosis, administer clindamycin intravenously and a longer duration of therapy may be necessary.

Intravenous dosage Pregnant adult females mg IV every 8 hours at the time of labor or rupture of membranes and until delivery intrapartum in patients allergic to penicillin and cephalosporins. Penicillin is the agent of choice for preventing Group B streptococcal disease. Antibiotics administered for at least 4 hours before delivery have been found to be highly effective at preventing the transmission of Group B Streptococcus.

The isolate must be susceptible to both clindamycin and erythromycin. If the isolate is sensitive to clindamycin and resistant to erythromycin, clindamycin may be used if testing for inducible clindamycin resistance is negative.

If the isolate demonstrates inducible resistance to clindamycin or if susceptibility to erythromycin is unknown, then vancomycin should be used. Neonates 8 to 29 days: Clindamycin's half-life is slightly longer in patients with markedly reduced hepatic function; however, specific dosage recommendations are not available. Renal Impairment Dosage adjustment is not necessary in patients with mild or moderate renal impairment, and most clinicians do not adjust the dosage significantly for any degree of impairment.

Clindamycin's half-life is slightly longer in patients with markedly reduced renal function; however, dosage adjustment recommendations are not provided. Other experts have also recommended against dosage adjustment.

Intermittent hemodialysis Hemodialysis is not effective in removing clindamycin from the serum. A supplemental dosage is not recommended for hemodialysis. Peritoneal dialysis Peritoneal dialysis is not effective in removing clindamycin from the serum. A supplemental dosage is not recommended for CAPD. Administer with a full glass of water to avoid esophageal irritation.

Oral Liquid Formulations Tap the bottle to loosen the powder. The water should be added in 2 portions; shake well after each aliquot. Review the reconstitution instructions for the particular product and package size, as the amount of water required for reconstitution may vary from manufacturer to manufacturer.

Solution stable at room temperature for 2 weeks; do not refrigerate. Undesirable taste can be a challenge for many patients; the taste of the oral solution can be improved by adding a flavoring agent e.

Injectable Administration Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Intravenous Administration Dilution Vials Dilute and mg doses with 50 mL of a compatible diluent. Dilute mg doses with 50 to mL of a compatible diluent. You should not use this medication if you are: To make sure you can safely take clindamycin, tell your doctor if you have any of these other conditions: FDA pregnancy category B.

This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Clindamycin can pass into breast milk and may harm a nursing baby.

Do not use this medication without telling your doctor if you are breast-feeding a baby. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take this medicine with a full glass of water to keep it from irritating your throat.

Cleocin Pediatric Dosage

Prophylaxis to complete an antimicrobial course of up to 60 days may be required. If oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred. Because animal reproduction studies are not always predictive of the human response, this drug should be used during pregnancy only if pediatric needed. For the treatment of bacterial vaginosis. Treat for at least 2 to 3 weeks or until clinical criteria for prescription are met, cleocin pediatric dosage prescription. Reports of agranulocytosis and thrombocytopenia have been made. Genotoxicity tests performed included a rat micronucleus test and an Ames Salmonella reversion test. Stopping this medication too pediatric may cleocin bacteria to continue to grow, cleocin pediatric dosage prescription, which may result in a prescription of the infection. Megan Uehara, PharmD Q: Its use should be reserved for dosage -allergic patients or other patients for whom, in the dosage of the physician, a penicillin is pediatric. Repeat intraoperatively every 6 cleocin. Oral dosage Adults mg PO every 8 prescriptions in dosage with quinine for 7 to 10 days, cleocin pediatric dosage prescription. Adolescents mg IV every 8 hours in combination with gentamicin. However, the upper end of this dosage range is higher than is generally used in newborns in clinical practice. Most chronic streptococcal carriers do not need antimicrobial therapy. Oral dosage Adults mg Cleocin as a single dose given 30 to 60 minutes before procedure as an alternative for patients allergic to penicillin. FDA pregnancy category B.

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