Before using chlorpromazine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Talk to your doctor about using chlorpromazine safely.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Talk to your doctor if you are using marijuana.

Before having surgery or imaging procedures such as certain X-rays, CT scans requiring the use of contrast dye such as metrizamide , tell your doctor or dentist that you are using this medication and about all the products you use including prescription drugs , nonprescription drugs, and herbal products.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Symptoms may include agitation or jitteriness and sometimes insomnia.

These symptoms often disappear spontaneously. At times these symptoms may be similar to the original neurotic or psychotic symptoms. Dosage should not be increased until these side effects have subsided.

If these symptoms become too troublesome, they can usually be controlled by a reduction of dosage or change of drug. Treatment with anti-parkinsonian agents, benzodiazepines or propranolol may be helpful. In most cases these symptoms are readily controlled when an anti-parkinsonism agent is administered concomitantly.

Anti-parkinsonism agents should be used only when required. Generally, therapy of a few weeks to 2 or 3 months will suffice. After this time patients should be evaluated to determine their need for continued treatment. Levodopa has not been found effective in antipsychotic-induced pseudo-parkinsonism.

Occasionally it is necessary to lower the dosage of Thorazine chlorpromazine or to discontinue the drug. As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued.

The syndrome can also develop, although much less frequently, after relatively brief treatment periods at low doses. This syndrome appears in all age groups. Although its prevalence appears to be highest among elderly patients, especially elderly women, it is impossible to rely upon prevalence estimates to predict at the inception of antipsychotic treatment which patients are likely to develop the syndrome.

The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw e.

Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia. A variant of tardive dyskinesia, tardive dystonia , has also been described. There is no known effective treatment for tardive dyskinesia; anti-parkinsonism agents do not alleviate the symptoms of this syndrome.

If clinically feasible, it is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked. It has been reported that fine vermicular movements of the tongue may be an early sign of the syndrome and if the medication is stopped at that time the syndrome may not develop. Adverse Behavioral Effects — Psychotic symptoms and catatonic-like states have been reported rarely.

Cerebral edema has been reported. Convulsive seizures petit mal and grand mal have been reported, particularly in patients with EEG abnormalities or history of such disorders. Abnormality of the cerebrospinal fluid proteins has also been reported. Allergic Reactions of a mild urticarial type or photosensitivity are seen. Avoid undue exposure to sun. More severe reactions, including exfoliative dermatitis , have been reported occasionally. Contact dermatitis has been reported in nursing personnel; accordingly, the use of rubber gloves when administering Thorazine chlorpromazine liquid or injectable is recommended.

In addition, asthma , laryngeal edema, angioneurotic edema and anaphylactoid reactions have been reported.

Lactation and moderate breast engorgement may occur in females on large doses. If persistent, lower dosage or withdraw drug. False-positive pregnancy tests have been reported, but are less likely to occur when a serum test is used. Amenorrhea and gynecomastia have also been reported. Hyperglycemia , hypoglycemia and glycosuria have been reported.

Special Considerations in Long-Term Therapy: Skin pigmentation and ocular changes have occurred in some patients taking substantial doses of Thorazine chlorpromazine for prolonged periods.

Skin Pigmentation — Rare instances of skin pigmentation have been observed in hospitalized mental patients, primarily females who have received the drug usually for 3 years or more in dosages ranging from mg to mg daily.

The pigmentary changes, restricted to exposed areas of the body, range from an almost imperceptible darkening of the skin to a slate gray color, sometimes with a violet hue. Histological examination reveals a pigment , chiefly in the dermis , which is probably a melanin-like complex.

The pigmentation may fade following discontinuance of the drug. Ocular Changes — Ocular changes have occurred more frequently than skin pigmentation and have been observed both in pigmented and nonpigmented patients receiving Thorazine chlorpromazine usually for 2 years or more in dosages of mg daily and higher. Eye changes are characterized by deposition of fine particulate matter in the lens and cornea. In more advanced cases, star-shaped opacities have also been observed in the anterior portion of the lens.

The nature of the eye deposits has not yet been determined. A small number of patients with more severe ocular changes have had some visual impairment. In addition to these corneal and lenticular changes, epithelial keratopathy and pigmentary retinopathy have been reported. Reports suggest that the eye lesions may regress after withdrawal of the drug.

If either of these reactions is observed, the physician should weigh the benefits of continued therapy against the possible risks and, on the merits of the individual case, determine whether or not to continue present therapy, lower the dosage, or withdraw the drug.

Mild fever may occur after large I. Hyperpyrexia has been reported. Increases in appetite and weight sometimes occur. Peripheral edema and a systemic lupus erythematosus-like syndrome have been reported. There have been occasional reports of sudden death in patients receiving phenothiazines.

In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex. The use of Thorazine chlorpromazine and other potential hepatotoxins should be avoided in children and adolescents whose signs and symptoms suggest Reye's syndrome.

Tardive dyskinesia , a syndrome consisting of potentially irreversible, involuntary , dyskinetic movements, may develop in patients treated with antipsychotic drugs. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome.

Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown. Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase.

However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses. There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn.

Antipsychotic treatment itself, however, may suppress or partially suppress the signs and symptoms of the syndrome and thereby may possibly mask the underlying disease process. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown.

Given these considerations, antipsychotics should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that, 1 is known to respond to antipsychotic drugs, and, 2 for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought.

The need for continued treatment should be reassessed periodically. If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics, drug discontinuation should be considered. However, some patients may require treatment despite the presence of the syndrome. A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with antipsychotic drugs.

Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure , tachycardia , diaphoresis and cardiac dysrhythmias. The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis , it is important to identify cases where the clinical presentation includes both serious medical illness e.

What Chlorpromazine Tablets are and what they are used for 2. What you need to know before you take Chlorpromazine Tablets 3. How to take Chlorpromazine Tablets 4. Possible side effects 5. How to store Chlorpromazine Tablets 6. Contents of the pack and other information 1. What Chlorpromazine Tablets are and what they are used for Chlorpromazine tablets belong to a group of drugs known as phenothiazines, which act on the central nervous system.

They are used to treat the following conditions: Chlorpromazine is also used for prolonged periods of hiccups, feeling or being sick when other drugs have failed , to lower body temperature and for childhood schizophrenia and autism learning and communication difficulties. What you need to know before you take Chlorpromazine Tablets Do not take Chlorpromazine Tablets and tell your doctor if you: Signs of an allergic reaction include: Warnings and precautions Talk to your doctor or pharmacist before taking Chlorpromazine Tablets if you: Your doctor may do blood tests to check on these have phaeochromocytoma high blood pressure due to a tumour near the kidney have glaucoma raised eyeball pressure have diabetes and are taking drugs to reduce blood sugar as Chlorpromazine Tablets may reduce their effect have enlargement of the prostate.

This means you may get infections more easily than normal you are elderly 65 years of age or older. Other medicines and Chlorpromazine Tablets Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines especially: Chlorpromazine Tablets with alcohol Alcohol must not be used with Chlorpromazine. This is because alcohol can increase the effects of Chlorpromazine and cause serious breathing problems.

Pregnancy and breast-feeding Talk to your doctor or pharmacist before having this medicine if you are pregnant, might become pregnant or think you may be pregnant.

The following symptoms may occur in newborn babies of mothers that have used Chlorpromazine in the last trimester last three months of their pregnancy: If your baby develops any of these symptoms you may need to contact your doctor.

Do not breast-feed if you are being given Chlorpromazine. If you are breast-feeding or planning to breast-feed talk to your doctor or pharmacist before taking this medicine. Chlorpromazine may make it difficult for a woman to get pregnant due to it reducing her fertility. Driving and using machines This medicine may cause some people, especially elderly patients, to become drowsy, dizzy, light-headed, clumsy, unsteady or less alert than normal. If you are affected, do not drive or operate dangerous machinery.

Chlorpromazine Tablets contain lactose If a doctor has told you that you have an intolerance to some sugars, check with your doctor before taking these tablets, as they contain a type of sugar called lactose. How to take Chlorpromazine Tablets Always take this medicine exactly as your doctor or pharmacist has told you.

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