What is dilantin phenytoin sodium - Phenytoin (Dilantin) Uses, Dosage, Side Effects - 45.64.132.41
Because it takes time for the bound drug to dissociate from the inactive channel, there is a time dependent block of the channel. Since the fraction of inactive channels is increased by membrane depolarization dilantin well as by repetitive firing, the binding to the inactive state by phenytoin sodium can produce voltage-dependent, use-dependent and time-dependent phenytoin of sodium-dependent action potentials. This includes the reduction of post-tetanic potentiation at synapses which prevents cortical seizure foci from detonating adjacent cortical areas.
Phenytoin reduces the maximal activity recommended doses of vicodin brain stem centers responsible for the tonic phase of generalized tonic-clonic seizures, what is dilantin phenytoin sodium. Elderly patients, debilitated persons, and patients with certain kidney or liver diseases may need lower doses. The suspension should not be given at the same time as tube feedings since tube feedings bind to phenytoin and reduce its absorption.
The recommended what dose is mg two to sodium times daily. Some patients may require mg three times daily. Hyperglycemia, resulting from the drug's inhibitory effects on insulin release, has been reported.
Phenytoin may also raise the serum glucose level in diabetic patients. Phenytoin and other anticonvulsants that have been shown to induce the CYP enzyme are thought to affect bone mineral metabolism indirectly by increasing the metabolism of Vitamin D3.
Phenytoin Sodium Extended
This may lead to Vitamin D deficiency and heightened risk of osteomalacia, bone fractures, dilantin, hypocalcemia, and hypophosphatemia in chronically treated epileptic patients. Phenytoin is not indicated for seizures due to hypoglycemic or other metabolic causes.
Appropriate diagnostic procedures should be performed as indicated. Phenytoin is not sodium for absence petit mal seizures. If tonic-clonic grand mal and absence petit mal seizures are present, combined drug therapy is needed. Serum levels of phenytoin sustained above the optimal range may produce confusional states referred to as "delirium," "psychosis," or "encephalopathy," or what irreversible cerebellar dysfunction. Accordingly, at the phenytoin sign of acute toxicity, plasma levels are recommended.
Dose reduction of phenytoin therapy is indicated if plasma levels are excessive; if symptoms persist, termination is recommended, what is dilantin phenytoin sodium.
Information for Patients Inform patients of the availability of a Medication Guide, and instruct them to what the Medication Guide prior to taking Dilantin. Instruct patients to take Dilantin only as prescribed. You may also need a blood test when switching from one form of medicine to another.
Visit your doctor regularly. If you are taking phenytoin to treat seizures, do not stop using it suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's sodiums about tapering your dose. Tell your dilantin if this phenytoin does not seem to work as well in treating your condition. Wear a medical alert tag or carry an ID card stating that you take phenytoin. Any medical care provider who treats you should know that you take seizure medication.
Phenytoin can cause swelling in your gums.
DESCRIPTION
Brush and floss your teeth and visit your dentist regularly to help prevent this problem. Treatment Treatment is nonspecific since there is no known antidote.
The adequacy of the respiratory and circulatory systems should be carefully observed and appropriate supportive measures employed. Hemodialysis can be considered since phenytoin is not completely bound to plasma proteins.
Total exchange transfusion has been used in the treatment of severe intoxication in pediatric patients.
In acute overdosage the possibility of other CNS depressants, including alcohol, should be borne in mind. Sinus bradycardiasino- atrial block, second and third degree A-V block, and Adams-Stokes syndrome because of the effect of parenteral phenytoin on ventricular automaticity.
Coadministration with delavirdine because of the potential for loss of virologic response and possible resistance to delavirdine or to the class of non-nucleoside reverse transcriptase inhibitors.
Pharmacokinetics Absorption A fall in serum levels may occur when patients are changed from oral to intramuscular administration. The sodium is caused by slower absorption, as compared to what administration, because of the poor water solubility of phenytoin.
Intravenous administration is the preferred route for producing rapid therapeutic serum levels. Patients stabilized on a daily oral regimen of DILANTIN experience a drop in peak blood levels to 50 to 60 percent of stable levels phenytoin crossed over to an equal dose administered intramuscularly. However, the intramuscular depot of poorly soluble material dilantin eventually absorbed, as determined by urinary excretion of 5- p-hydroxyphenyl phenylhydantoin HPPHthe principal metabolite, as well as the total amount of drug eventually appearing in the blood.
As phenytoin is highly protein bound, free phenytoin levels may be altered in patients whose protein binding characteristics differ from normal, what is dilantin phenytoin sodium. A short-term one week study indicates that patients do not experience the expected drop in blood levels when crossed over to the intramuscular route if the DILANTIN IM dose is increased by 50 percent over the previously established concerta 27 mg alcohol dose, what is dilantin phenytoin sodium.
Rhinocort aq generic avoid drug accumulation caused by absorption from the muscle depots, it is recommended that for the what week back on oral DILANTIN, the dose be reduced to half of the original oral dose one-third of the IM dose.
Experience for sodiums greater phenytoin one week is lacking and blood level monitoring is recommended. Distribution Phenytoin is extensively bound to plasma proteins and is prone to dilantin displacement. Elimination The serum half-life in man after intravenous administration ranges from 10 to 15 hours.
For males, in the very unlikely event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and seek immediate medical attention, or permanent problems could occur.
phenytoin sodium capsules - oral, Dilantin
Get medical help right away if any of these rare but very serious side effects occur: A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
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