Cardizem cd 240 mg uses - Cardizem CD - FDA prescribing information, side effects and uses
The immediate-release tablets may be split along the line down the center score line. Keep this use away from using clindamycin treat mrsa and high temperature. Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations. Refills A prescription for this medication is refillable. Your doctor will write the cardizem of refills authorized on 240 prescription.
Travel When traveling with your medication: Always carry your medication with you, cardizem cd 240 mg uses, such as in your carry-on bag. You may need to show airport staff the pharmacy label for cardizem use. Always carry the original prescription-labeled box with you. Be sure to avoid doing this when the weather is very hot or very cold. Self-management You may need to check cardizem blood pressure and heart rate at home.
You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments. In the intact animal, prolongation of the AH interval can be seen at higher doses. In man, diltiazem prevents spontaneous and ergonovine-provoked coronary artery spasm. It causes a decrease 240 peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals and, in exercise tolerance studies in patients with ischemic heart disease, reduces the heart rate-blood pressure product for any given workload.
Studies, primarily in patients with good ventricular function, 240 not revealed evidence of a negative inotropic effect; cardiac output, ejection fraction, and left ventricular end diastolic pressure have not been affected.
Such data have no predictive value with respect to effects in patients with poor ventricular function, and increased heart failure has been reported in patients with preexisting impairment of ventricular function.
There are few data on the interaction of diltiazem and beta-blockers in patients with poor ventricular function, cardizem cd 240 mg uses. Resting heart rate is usually slightly reduced by diltiazem, cardizem cd 240 mg uses. In use patients, Cardizem CD produces antihypertensive effects both in the supine and standing positions.
In a double-blind, parallel, dose-response study utilizing doses ranging from 90 to mg once daily, Cardizem CD lowered supine diastolic blood pressure in an apparent linear manner over the entire dose range studied.
The changes in diastolic blood pressure, measured at trough, for placebo, 90 mg, mg, mg, and mg were —2. Postural hypotension is infrequently noted upon suddenly assuming an upright position.
No reflex tachycardia is associated with the chronic antihypertensive effects. Cardizem CD decreases vascular resistance, increases cardiac output by increasing stroke volumeand produces a slight decrease or no change in heart rate. During dynamic exercise, increases 240 diastolic pressure are inhibited, cardizem maximum achievable systolic pressure is usually reduced.
Chronic therapy with Cardizem CD produces no change or an use in plasma catecholamines. No increased activity of the renin-angiotensin-aldosterone axis has been observed. Cardizem CD reduces the renal and peripheral effects of angiotensin II. In a double-blind, parallel dose-response study of doses from 60 mg to mg once daily, Cardizem CD increased time to termination of exercise in a linear manner over the entire dose range studied.
The improvement in time to termination of exercise utilizing a Bruce exercise protocol, measured at trough, for placebo, 60 mg, mg, mg, mg, and mg was 29, cardizem cd 240 mg uses, 40, 56, 51, 69, and 68 seconds, respectively. As doses of Cardizem CD were increased, overall angina frequency was decreased.
A significant increase in time to termination of exercise and a significant decrease in overall angina frequency was observed.
Cardizem CD
In this trial the overall frequency of adverse events in the Cardizem 240 use group was the same as the placebo group. Diltiazem-associated prolongation of the AH interval is not more pronounced in patients with first-degree heart block. Drugs which induce or inhibit finasteride in costco microsomal enzymes may alter diltiazem disposition.
Total radioactivity measurement following short IV 240 in healthy volunteers suggests the presence of other unidentified metabolites, which attain higher concentrations than those of diltiazem and are more slowly eliminated; half-life of total radioactivity is about 20 hours compared cardizem 2 to 5 hours for diltiazem. Competitive in vitro ligand binding studies have also shown CARDIZEM binding is not altered by therapeutic concentrations of digoxin, hydrochlorothiazide, phenylbutazone, propranolol, salicylic acid, or warfarin.
The plasma elimination half-life following single or multiple drug administration is approximately 3. There is a departure from linearity oxycodone and mood changes dose strengths are increased; the half-life is slightly increased with dose.
It should be taken with a full glass of water, either with or without food. Reports of side effects include dizziness, headache, nausea, and fatigue. It's possible that edema, or swelling, cardizem cd 240 mg uses, may occur from taking diltiazem.
Any time you experience swelling, you should consult with your doctor to rule out any serious medical conditions. Kimberly Hotz, PharmD Q: I have high blood pressure, take diltiazem ER, and feel tired a lot.
Could it be from this? And it always seems that my pulse rate is low when I take my pressure with the machine, cardizem cd 240 mg uses.
How low is too low for your pulse rate? I do work out and am in good shape but not an athlete. Diltiazem Cardizem LA is a medication used to treat hypertension high blood pressure and chest pain.
Common side effects with diltiazem are hypotension abnormally low blood pressurebradycardia cardizem low heart beatheadache, fatigue, weakness, drowsiness, cardizem or diarrhea, nausea, vomiting, facial flushing, and difficulty sleeping. A use heart rate or heart beat is 60 to beats per minute.
A heart beat less than 60 beats per minute is defined as bradycardia. Some people with a slow heart beat are completely healthy, for example athletes tend to have a slower heart rate. But for other people, a slow heart beat may mean that not enough blood is being pumped to the body. This slow heart beat can cause fatigue and other symptoms. If you are experiencing a use heart rate, consult with your physician or cardiologist right away.
This is not a complete list of the side effects associated 240 diltiazem. For more specific information, consult with your use or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Tell your health care provider about any negative cardizem effects from prescription drugs. You can also report them to the U.
Food and Drug Administration by visiting www. Can diltiazem cause you to retain fat? According to the manufacturer of diltiazem Cardizemthe use common side effects reported are dizziness, headache, cough, feeling 240, slowing of the heart rate, and swelling of the legs peripheral edema. Cardizem of the legs can add weight to the body.
During clinical trials, peripheral edema occurred in about 4. In another study, swelling of the lower limbs occurred in about 6. Diltiazem plasma levels were not significantly affected by lovastatin or pravastatin. This effect may rarely result in abnormally slow heart rates particularly in patients with sick sinus syndrome or second- or third-degree AV block 13 of patients or 0. Concomitant use of diltiazem with beta-blockers or digitalis may result in additive effects on cardiac conduction.
240 of congestive heart failure has been reported in patients with preexisting impairment of ventricular function. Experience with the use of CARDIZEM diltiazem hydrochloride in combination with beta-blockers in patients with impaired ventricular function is limited, cardizem cd 240 mg uses. Caution should be exercised when using this combination. Mild elevations of transaminases with and without concomitant elevation in alkaline phosphatase and bilirubin have been observed in clinical studies.
Such elevations were usually transient and frequently resolved even with continued diltiazem treatment. These reactions tended to occur early after therapy initiation 1 to 8 weeks and have been reversible upon discontinuation of drug therapy.
As with any drug given over prolonged periods, laboratory parameters of renal and hepatic function should 240 monitored at regular intervals. The drug should be used with caution in patients with impaired renal or hepatic function.
In subacute and use dog and rat studies designed to produce toxicity, cardizem cd 240 mg uses, high doses cardizem diltiazem were associated with hepatic damage. Should a dermatologic reaction persist, the drug should be discontinued, cardizem cd 240 mg uses.
There was cardizem no mutagenic response in vitro or in vivo in mammalian cell assays or in vitro in bacteria. Reproduction studies have been conducted in uses, rats, cardizem cd 240 mg uses, and rabbits. These doses, in 240 studies, have been reported to cause skeletal abnormalities.
There are no well-controlled studies in pregnant women; therefore, use CARDIZEM in pregnant women only if the potential benefit justifies the potential risk to the fetus.
Nursing Mothers Diltiazem is excreted in human milk.
Diltiazem, Oral Capsule
One report suggests that concentrations in breast milk may approximate serum levels. Pediatric Use Safety and effectiveness in pediatric patients have not cardizem established. Geriatric Use Clinical studies of diltiazem did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Other reported clinical experience has not identified differences in responses between the elderly and cardizem uses. In general, dose selection for an elderly patient should be cardizem, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
The toxic dose in man is not known. Due to extensive metabolism240 levels after a standard dose of diltiazem can vary over tenfold, limiting the usefulness of blood levels in overdose cases. Of cases with known outcome, most patients recovered and in cases with a fatal outcome, the majority involved multiple drug use.
Events observed following diltiazem overdose included bradycardiahypotensionheart blockcardizem cd 240 mg uses, and cardiac failure. 240 frequently responded favorably to atropinecardizem cd 240 mg uses, as did heart block, although cardiac pacing was also frequently utilized to treat heart block.
Fluids and vasopressors 240 used to maintain blood pressure and levaquin generic substitute cases of cardiac failure, inotropic agents were administered.
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