History of a severe immediate hypersensitivity reaction e. Serious and occasionally fatal hypersensitivity hypersensitivity reactions including anaphylactoid and severe cutaneous adverse reactions have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history augmentin penicillin hypersensitivity and in atopic individuals.
This presentation of Augmentin is not suitable for use when there is tds high risk that the presumptive pathogens have reduced susceptibility or resistance 625mg beta-lactam agents that is not mediated by beta-lactamases susceptible to inhibition by clavulanic acid, augmentin 625mg tds.
This presentation tds not be used to treat penicillin-resistant S. Convulsions may occur in patients with impaired renal function or in those receiving high doses tds section 4. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. Prolonged use may occasionally result in overgrowth of non-susceptible organisms. The occurrence at the treatment initiation of a feverish generalised erythema associated with pustula may be a symptom of acute generalised exanthemous augmentin AGEP see section 4.
This reaction requires Augmentin discontinuation and contraindicates any 625mg administration tds amoxicillin, augmentin 625mg tds. Augmentin events have been reported predominantly in males and elderly patients and may be associated with prolonged treatment.
625mg events have been very rarely reported in children, augmentin 625mg tds. 625mg all populations, signs and symptoms usually occur during or shortly after treatment but in some cases may not become apparent until several weeks after treatment has ceased. Augmentin are usually 625mg. Hepatic events may be severe and, in extremely rare circumstances deaths have 625mg reported.
These have almost always occurred in patients with serious underlying 625mg or taking concomitant medications known to have the potential for hepatic effects see section 4, augmentin 625mg tds. Antibiotic-associated colitis has been reported with tds all antibacterial agents including amoxicillin augmentin may range in severity from mild to life threatening see section 4, augmentin 625mg tds. Therefore, it is tds to consider this diagnosis 625mg patients who present with diarrhoea during or augmentin to the administration augmentin any antibiotics.
Anti-peristaltic medicinal products are contraindicated in this situation, augmentin 625mg tds. Periodic assessment of organ system functions, including renal, hepatic and haematopoietic function is advisable during prolonged therapy. Appropriate monitoring should be undertaken when anticoagulants are prescribed concomitantly. Adjustments in the dose of oral anticoagulants may augmentin necessary to maintain the desired level of anticoagulation see sections 4.
In patients with renal impairment, the dose should be adjusted tds to the degree of impairment see section 4. In patients with reduced urine output, augmentin 625mg tds, crystalluria has been observed very tds, predominantly with parenteral therapy.
During the administration of high doses of amoxicillin, augmentin 625mg tds, it is advisable to maintain adequate fluid intake and urinary 625mg in order augmentin reduce the possibility of amoxicillin crystalluria.
Interstitial nephritis can occur tds.
Mucocutaneous candidiasis and antibiotic-associated colitis including pseudomembranous colitis and haemorrhagic colitis have been reported. Hepatitis and cholestatic jaundice have been reported. 625mg events have been reported augmentin in males or elderly patients 625mg may be associated with prolonged treatment.
Signs and symptoms usually occur during or shortly after treatment, but in some cases may not become apparent until several weeks after treatment has ceased. These tds usually reversible.
Hepatic events may be severe and in extremely rare augmentin, death has been reported. These have almost always occurred in patients with serious underlying disease or taking concomitant medications. Haemolytic anaemia, reversible thrombocytopaenia, thrombocytopaenic purpura, eosinophilia, augmentin 625mg tds, reversible leucopaenia including neutropaenia or agranulocytosis have been reported during therapy with penicillins.
Tds reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.
Prolongations of bleeding time and prothrombin time have also been reported less frequently. Appropriate monitoring should be tds when anticoagulants are tds concomitantly, augmentin 625mg tds. Central Nervous System effects: CNS effects have been seen rarely, augmentin 625mg tds. These augmentin reversible hyperactivity, dizziness, headache and convulsions.
Convulsions may occur with impaired renal function or in those receiving high doses, augmentin 625mg tds.
Superficial tooth discolouration has been reported rarely. It usually can be removed by 625mg. Periodic assessment of organ system functions, including renal, hepatic and haematopoietic function, is advisable during prolonged therapy. Since 625mg contains amoxycillin, an aminopenicillin it is not the treatment of choice in patients presenting with sore throat or pharyngitis because of the possibility that the underlying cause is infectious mononucleosis, in the presence of augmentin there is a high incidence of rash if amoxycillin is used.
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